沈卫军博士是国际著名新药转化研发专家。在小分子药物发现、高通量筛选、治疗性多肽工程等方面具有丰富的研发经验。主持和参与50多个新药研发项目，并与制药企业达成多项技术转让和项目的合作；针对炎性肠炎（IBD）的长效GLP2多肽药物和针对帕金森综合症的长效GM-CSF抗体药目前正在美国进行临床1期的试验；针对糖尿病和非酒精性脂肪肝的长效多肽GLP1R/GIPR双激动剂正在美国开展临床申报实验，还有多种临床前候选药物将在两年内进入临床申报（IND）和临床研究阶段。
拥有超过15项专利，在各类高影响因子同行评议期刊中发表了40余篇论文（包括Nature, Nature Chem Biol, Nature Communications, Nature Chemistry, Science Advances, PNAS, JACS, ACIE, JMC等)。
电子邮箱
wshen@szbl.ac.cn
个人经历
教育背景
University of Nebraska生物有机化学(博士);
The Scripps Research Institute化学生物学 (博士后)
工作经历
Scripps研究所 Peter G. Schultz教授研究组,助理研究员（化学生物学）(2007-2009）
诺华制药研究基金会基因组学研究所首席研究员（β细胞生物学）、课题组长 (2009-2012）
Calibr（加州生物医药研究所）创所首席研究员（疾病生物学、肽工程） (2012-2018）
Scripps研究所/Calibr首席研究员 (2018-2019)
Scripps研究所/Calibr代谢病总监 (2019-2022)
深圳湾试验室资深研究员，转化医学中心主任（2022-）
研究方向
主要聚焦于化学生物学和针对癌症、代谢及炎症类、神经退行性疾病等重大疾病的新药研发
个人荣誉
1、荣获国家科技部2022“火炬”计划
2、荣获深圳市高层次人才认定
3、担任内布拉斯加大学化学系的工业咨询委员会顾问、美国多肽协会会员、美国糖尿病协会会员、美中生物科技与制药专业协会 (SABPA）的理事会理事、太平洋联盟委员会主席。
科研项目
1、一种用于治疗的蛋白酶重组表达技术工艺探索及优化企业合作横向项目，负责人
2、小分子药物高通量筛选和新药研发应用研究-JDRF (儿童糖尿病协会)境外合作，主持
3、多肽工程技术平台脂肪酸联装技术平台技术开发和长效多肽药物研发应用研究- Calibr sponsored research 境外合作，主持
4、小分子药物高通量筛选和新药研发应用研究- Calibr sponsored research境外合作，主持
代表论著
1.Valeria Marrocco*, Tran Tran, Siying Zhu, Seung Hyuk Choi, Ana M. Gamo, Sijia Li, Qiangwei Fu, Marta Diez Cunado, Jason Roland, Mitch Hull, Van Nguyen-Tran, Sean Joseph, Gokhan Hotamisligil, Arnab K. Chatterjee, Nikki Rogers, Matthew S. Tremblay, and Weijun Shen*，A Small Molecule UPR Modulator for Diabetes Identified by High Throughput Screening, Acta Pharmaceutica Sinica B, 2021(in press)
2.Yahu Liu*, Qihui Jin, Yefen Zou, Qiang Ding, Shanshan Yan, Zhicheng Wang, Xueshi Hao, Bao Nguyen, Xiaoyue Zhang, Jianfeng Pan,Tingting Mo, Kate Jacobsen, Thanh Lam, Tom Wu, Michael H. Petrassi, Badry Bursulaya, Michael DiDonato, W Gordon, Bo Liu, Janine Baaten, Robert Hill, Van Nguyen-Tran, Minhua Qiu, You-Qing Zhang, Anwesh Kamireddy, Sheryll Espinola, LIsa Deaton, Sukwon Ha, George Harb, Yong Jia, Jing Li, Weijun Shen, Andrew Schumacher, Karyn Colman, Richard Glynne, Shifeng Pan, Peter McNamara, Bryan Laffitte, Shelly Meeusen, Valentina Molteni, Jon Loren*，Selective DYRK1A inhibitor for the treatment of Type 1 Diabetes: Discovery of 6-azaindole derivative GNF2133, J. Med. Chem.2020.
3.Amin Ardestani*, Sijia Li*, Karthika Annamalai, Blaz Lupse, Shirin Geravandi, Aleksandra Dobrowolski, Shan Yu, Siying Zhu, Tyler D. Baguley, Murali Surakattula, Janina Oetjen, Lena Hauberg-Lotte, Raquel Herranz, Sushil Awal, Delsi Altenhofen, Nguyen-Tran, Sean Joseph, Peter G Schultz, Arnab K. Chatterjee, Nikki Rogers, Matthew S. Tremblay*, Weijun Shen* and Kathrin Maedler*，Neratinib Protects Pancreatic Beta Cells in Diabetes, Nature Communications, 2019.
4.Amin Ardestani*, Matthew S. Tremblay, Weijun Shenand Kathrin Maedler*, Neratinib is an MST1 inhibitor and restores pancreatic β-cells in diabetes, Cell Death Discovery,2019 Dec 5;5:149. doi: 10.1038/s41420-019-0232-0
5.Zhihong Huang*, Matthew S. Tremblay, Tom Y.-H.Wu, Qiang Ding, Xueshi Hao, Janine E.Baaten, RobertW. Hill, Bo Liu, Shelly Meeusen, Yefen Zou, Shanshan Yan, Yong Jia, Van Nguyen-Tran, Weijun Shen,Ganesh Bhat, Richard Glynne, Bryan Laffitte, Jing Li, Valentina Molteni*, and Yahu A. Liu*, Discovery of5-(3,4-difluorophenyl)-3-(pyrazol-4-yl)-7-azaindole (GNF3809) for β cell survival in type 1 diabetes, ACS Omega,2019, 4(2):3571-3581
6.Linlin Zhong*, Tuan Tran*, Tyler D Baguley, Sang Jun Lee, Adam Henke, Andrew To, Sijia Li, Shan Yu, Fabio A Grieco, Jason Roland, Peter G Schultz, Decio L Eizirik, Nikki Rogers, Arnab K Chartterjee, Matthew S Tremblay, and Weijun Shen*, A Novel Inhibitor of inducible NOS Dimerization protects against cytokine-induced rat beta cell dysfunction, British Journal of Pharmacology,2018,175(17):3470-3485
7.Xueshi Hao*, Qihui Jin, Porino Va, Chun Li, Weijun Shen, Bryan Laffitte, and Tom Y.-H. Wu*，Pancreas-Specific Delivery of β-Cell Proliferating Small Molecule, Chem Med Chem., 2016
8.Weijun Shen*, Brandon Taylor, Qihui Jin, Van Nguyen-Tran, Shelly Meeusen, You-Qing Zhang,Anwesh Kamireddy, Austin Swafford, Andrew F. Powers, John Walker , John Lamb, Badry Bursalaya,Michael DiDonato, George Harb, Minhua Qiu , Christophe M. Filippi, Lisa Deaton, Carolina N. Turk,Wilma L. Suarez-Pinzon, Yahu Liu, Xueshi Hao, Tingting Mo, Shanshan Yan, Jing Li, Ann E. Herman,w ,Bernhard J. Hering, Tom Wu, H. Martin Seidel, Peter McNamara, Richard Glynne* & Bryan Laffitte*, Inhibition of DYRK1A and GSK3B induces humanβ-cell proliferation, Nature Communications,2015,6:8372
9.Weijun Shen*, Matthew S Tremblay*, Vishal A Deshmukh, Weidong Wang, Christophe M Filippi, George Harb, You-qing Zhang, Anwesh Kamireddy, Janine E Baaten, Qihui Jin, Tom Wu, Jonathan G Swoboda, Charles Y Cho, Jing Li, Bryan A Laffitte, Peter McNamara, Richard Glynne, Xu Wu, Ann E Herman, and Peter G Schultz*,Small- molecule inducers of β cell proliferation identified by high-throughput screening, J. Am. Chem. Soc., 2013.
10.Peng Sang*,Hongxiang Zeng,Candy Lee,Yan Shi1,Minghui Wang,Cong Pan,Lulu Wei,Chenglong Huang,Mingjun Wu,Weijun Shen*,Xi Li*,Jianfeng Cai*, α/Sulfono-γ-AApeptide Hybrid Analogues of Glucagon with Enhanced Stability and Prolonged In Vivo Activity, J Med Chem,2021 Sep 23;64(18):13893-13901.
11.Peng Sang*, Zhihong Zhou, Yan Shi,Candy Lee, Zaid Amso, David Huang, Timothy Odom, Vân T.B. Nguyen-Tran, Weijun Shen*,Jianfeng Cai*,The Activity of Sulfono-γ-AApeptide Helical Foldamers That Mimic GLP-1,Science Advances 2020.
12.Sam Lear*, Elsa Pflimlin*, Zhihong Zhou*, David Huang, Van T.B. Nguyen-Tran, Sean B. Joseph, Shane Roller, Scott Peterson, Jing Li, Matthew Tremblay, Peter G. Schultz and Weijun Shen*,Engineering of a Potent, Long-Acting NPY2R Agonist for Combination with a GLP-1R Agonist as a Multi-Hormonal Treatment for Obesity, J. Med. Chem.,2020.
13.Peng-Yu Yang*, Huafei Zou,Zaid Amso, Candy Lee, David Huang, Ashley K. Woods, Vân T. B. Nguyen-Tran, Peter G. Schultz* and Weijun Shen*,New Generation Oxyntomodulin Peptides with Improved Pharmacokinetic Profiles Exhibit Weight Reducing and Anti-steatotic Properties in Mice,Bioconjugate Chem.2020
14.Elsa Pflimlin*, Zhihong Zhou, Zaid Amso, Qiangwei Fu, Candy Lee, Avinash Muppidi, Sean B. Joseph, Vân Nguyen-Tran, and Weijun Shen*，Engineering a potent, long-acting, and periphery-restricted oxytocin receptor agonist with anorexigenic and body weight reducing effects, J. Med. Chem., 2020, 63, 382-390.
15.Sam Lear*, Hyosuk Seo, Candy Lee, Lei Lei, Zaid Amso, David Huang, Huafei Zou, Zhihong Zhou, Vân T.B. Nguyen-Tran and Weijun Shen*，Recombinant Expression and Stapling of a Novel Long-Acting GLP-1R Peptide Agonist, Molecules, 2020.
16.Hiroshi Deguchi*, Zihan Guo, Mohammed Hayat, Elsa Pflimlin, Sam Lear,Weijun Shen*and John H.Griffin*,Molecular interaction site on procoagulant myosin for factor Xa-dependent prothrombinactivation, J. Biol. Chem.2019,294(41):15176-15181.
17.Elsa Pflimlin*,Sam Lear,Candy Lee,Shan Yu, Huafei Zou, Andrew To,Sean Joseph,Van Nguyen-Tran, Matthew S. Tremblay and Weijun Shen*,Design of a Long-Acting and Selective MEG-Fatty Acid Stapled Prolactin-Releasing Peptide Analog,ACS Med. Chem. Lett.,2019,10(8):1166-1172
18.Avinash Muppidi*, Sang Jun Lee, Che-Hsiung Hsu, Huafei Zou, Candy Lee, Elsa Pflimlin, Madhupriya Mahankali, Pengyu Yang, Elizabeth Chao, Insha Ahmad, Andreas Crameri, Danling Wang, Ashley Woods, and Weijun Shen*,Design and Synthesis of Potent, Long-Acting Lipidated Relaxin-2 Analogs,Bioconjugate Chem.,2019, 30(1):83-89.
19.Peng-Yu Yang*, Huafei Zou, Elizabeth Chao, Lance Sherwood, Vanessa Nunez, Michael Keeney, Esi Ghartey-Tagoe, Zhongli Ding, Herlinda Quirino, Xiaozhou Luo, Gus Welzel, Guohua Chen, Parminder Singh, Ashley K. Woods*, Peter G. Schultz* ,and Weijun Shen*，Engineering a long-acting, potent GLP-1 analog for microstructure-based transdermal delivery, Proc Natl Acad Sci USA, 2015.
20.Sophia Z. Shalhout*, Peng-Yu Yang*, Edyta Grzelak, Kayla Nutsch, Sida Shao, Claudio Zambaldo, Jonathan Edyta, Lara Ibrahim, Caroline Stanton, Stormi Chadwick, Emily Chen, Michael DeRan, Sijia Li, Mitchell Hull, Xu Wu, Arnab Chatterjee, Weijun Shen*, Fernando Camargo*, Peter G. Schultz* & Michael J. Bollong*，YAP-dependent Proliferation by a Small Molecule Targeting Annexin A2, Nature Chemical Biology, 2021
21.Xuekai Zhang*, Gang Lu, Meng Sun, Madhu Mahankali, Yanfei Ma, Mingming Zhang, Wangde Hua, Yuting Hu, Qingbing Wang, Jinghuo Chen, Gang He*, Xiangbing Qi*,Weijun Shen*, Peng Liu* and Gong Chen*,A General Strategy for Synthesis of Cyclophane-Braced Peptide Macrocycles via Palladium-Catalyzed Intramolecular sp3 C−H Arylation,Nature Chemistry,2018,10.1038/s41557-018-0006-y
22.Seung H. Choi*, Madhupriya Mahankali, Sang Jun Lee, Mitch Hull, H. Michael Petrassi, Arnab K. Chatterjee, Peter G Schultz*, Katherine A. Jones*,and Weijun Shen*,Targeted disruption of Myc-Max oncoprotein complex by a small molecule,ACS Chem.Biol.,2017,Nov 17,12(11):2715-2719.
23.Sang Jun Lee*, Madhupriya Mahankali, Abdallah Bitar, Huafei Zou, Elizabeth Chao, Hung Nguyen, Jose Gonzalez, Dawna Caballero, Mitch Hull, Danling Wang, Peter G Schultz, & Weijun Shen*,A Novel Role for RARa Agonists as Apolipoprotein CIII Inhibitors Identified from High Throughput Screening, Scientific Reports, 2017
24.Chris J. Novotny*, Sirkku Pollari, Jin H. Park, Mark A. Lemmon, Weijun Shen* & Kevan M. Shokat*,Overcoming Resistance to HER2 Inhibitors Through State-Specific Kinase Binding, Nature Chem. Biol.,2016.
25.Christopher D. McCune*, Su Jing Chan, Matthew L. Beio, Weijun Shen, Woo Jin Chung, Laura M. Szczesniak, Chou Chai, Shu Qing Koh, Peter T.-H. Wong*,and David B. Berkowitz*, “Zipped Synthesis” by cross-metathesis provides a cystathionine β‑synthase inhibitor that attenuates cellular H2S levels and reduces neuronal infarction in a rat ischemic stroke model, ACS Central Sciences, 2016
26.Sebastien Hannedouche*, Juan Zhang,Tangshen Yi(co-first authors), Weijun Shen, DeborahNguyen, Danilo Guerini, Birgit Baumgarten, Silvio Roggo, Ben Wen, Richard Knochenmuss, Sophie Noel, Francois Gessier, Mirka Vanek, Stephane Laurent, Charlotte Miault, Wei Li, Dong-In Koo, Thomas Suply, Christian Schmedt, Eric C. Peters,Rocco A. Falchetto, Andreas Katopodis, Carsten Spanka, Marie-Odile Roy, Michel Detheux, YuAlice Chen, Peter G. Schultz, Charles Y. Cho, Klaus Seuwen, Jason G. Cyster & Andreas W. Sailer*,Oxysterols direct immune cell migration via EBI2,Nature,2011, 475 (7357),524-527
27.Anna Dubrovska*, Chanhek Kim, Jimmy Elliott,Weijun Shen, Tun Hsun Kuo, Dong-InKoo, Chun Li, Tove Tungland, Jonathan Change, Todd Groessl, Xu Wu, Vanessa Gorney, Teresa Ramirez-Montagut, David A spiegel, Charles Cho,and Peter G Schultz*,A Chemically induced vaccine strategy for prostate cancer, ACS Chemical Biology, 2011, 6(11):1223-31
28.Hui-Wang Ai*, Weijun Shen(Co-first authors), Peng R. Chen, and Peter G Schultz*,Probing protein-protein interactions with a genetically encoded photo-crosslinking amino acid, ChemBioChem,2011, 12,1854-1857
29.Hui-Wang Ai*, Weijun Shen, Eric Brustad, and Peter G Schultz*，Genetically encoded alkenes in yeast,Angew. Chem. Int. Ed. Engl.,2010
