中山大学“百人计划”教授，博士生导师。国家重点人才工程入选者，广东省杰出青年基金获得者，广东省珠江人才计划引进创新团队核心成员兼委托负责人，主要从事病原微生物群体感应、胞内信号传导及致病机理、新型抗菌药物研究等。在Chem Rev、PNAS（3篇）、ISME J（2篇）、Nat Chem Biol、Environ Microbiol、MPP、Mol Microbiol、Appl Environ Microbiol、AAC 等权威期刊发表SCI论文近50篇。申请国际发明专利7项, 授权4项;申请国家发明专利28项, 授权18项。主持包括国家重点研发计划课题、973子课题、国自然面上项目、深圳市基础研究重点项目等科研项目。是多个省部级科研和人才项目评审专家，也是Nat Commun、PNAS、ISME J等40多个期刊审稿人。
电子邮箱
本课题组长期招收博士后，联系地址：dengyle@mail.sysu.edu.cn
个人经历
1997.09-2001.06: 南开大学微生物学专业本科毕业，获学士学位
2001.09-2004.06: 南开大学微生物学专业硕士研究生毕业，获硕士学位
2006.01-2010.01: 新加坡国立大学生物科学系博士研究生毕业, 获博士学位
2010.02-2014.03: 新加坡科技研究局分子细胞生物学研究所 研究员/高级研究员
2014.04-2019.03: 华南农业大学 教授、博导
2019.04-至今 中山大学药学院（深圳）“百人计划”教授、博导
研究方向
1. 微生物群体感应信号系统
2. 细菌胞内第二信使
3. 微生物-宿主跨界通讯与互作
4. 新型抗菌药物研发
科研项目
【01】广东省珠江人才计划创新团队,期限:2013.07-2018.06,团队核心成员与委托负责人。
【02】华南农业大学丁颖人才培养工程(国家级二级),期限:2016.01-2019.12。
【03】2015年国家海外高层次人才计划。
【04】广东省自然科学杰出青年基金,期限:2015.01-2018.12，主持。
【05】国家自然科学基金面上项目,期限:2016.01-2019.12，主持。
【06】国家重点基础研究发展计划(973课题)子课题,期限:2015.01-2019.12，主持。
【07】广州市珠江科技新星项目,期限:2015.04-2018.03，主持。
【08】国家自然科学基金重点项目,期限:2019.01-2023.12，参与。
【09】深圳市基础研究重点项目,期限:2020.11-2023.11，主持。
【10】国家重点研发计划课题，期限2021.12-2026.11，主持。
代表论著
近5年代表性论著
1. Quan Guo, Binbin Cui, Mingfang Wang, Xia Li, Huihui Tan, Shihao Song, Jianuan Zhou, Lian-Hui Zhang, Yinyue Deng*. A novel cyclic dimeric guanosine monophosphate effector modulates Acinetobacter baumannii physiology and virulence. Proc. Natl. Acad. Sci. U.S.A. (Revision).
2. Shihao Song, Xiuyun Sun, Quan Guo, Binbin Cui, Yu Zhu, Xia Li, Jianuan Zhou, Lian-Hui Zhang, Yinyue Deng*. An anthranilic acid-responsive transcriptional regulator controls the physiology and pathogenicity of Ralstonia solanacearum. PLoS Pathogens. (Minor Revision)
3. Ye P#, Li X#, Cui B#, Song S#, Shen F, Chen X, Wang G, Zhou X, Deng Y*. Proline utilization A controls bacterial pathogenicity by sensing its substrate and cofactors. Communications Biology. (Minor Revision).
4. Yan X#, Yang C#, Yong Y, Wang M, Deng Y*, Gao Y*. (2022) Structural basis of the ATPase domain of GtrR as a downstream transcriptional regulator of the BDSF quorum sensing system in Burkholderia cenocepacia. FEBS Letters. 596(1):71-80.
5. Wang M#, Li X#, Song S#, Cui C, Zhang LH, Deng Y*. (2022) The cis-2-dodecenoic acid (BDSF) quorum sensing system in Burkholderia cenocepacia. Appl Environ Microbiol. 88(4):e0234221.
6. Yang J, Wang HH, Lu Y, Yi LX, Deng Y, Lv L, Burrus V, Liu JH. (2021) A ProQ/FinO family protein involved in plasmid copy number control favours fitness of bacterial carrying mcr-1-bearing Incl2 plasmids. Nucleic Acids Res. 49(7):3981-3996.
7. Wang K#, Li X#, Yang C, Song S, Cui C, Zhou X, Deng Y*. (2021) A LysR family transcriptional regulator modulates Burkholderia cenocepacia biofilm formation and protease production. Appl Environ Microbiol. 87(12):e0020221.
8. Song S#, Sun X#, Meng L, Wu Q, Wang K, and Deng Y*. (2021) Antifungal activity of hypocrellin compounds and their synergistic effects with antimicrobial agents against Candida albicans. Microbiol Biotech. 14(2):430-443.
9. Song#, Yin W#, Sun X, Cui B, Huang L, Li P, Yang L, Zhou J, Deng Y*. (2020) Anthranilic acid from Ralstonia solanacearum plays dual roles in intraspecies signalling and inter-kingdom communication. The ISME Journal. 14：2248-2260.
10. Shen F#, Yin W#, Song S#, Zhang Z, Ye P, Zhang Y, He F*, Li P*, and Deng Y*. (2020) Ralstonia solanacearumpromotes pathogenicity by utilizing L-glutamic acid from host plants. Mol Plant Pathol. 21：1099-1110.
11. Meng L#, Sun C#, Zhang C, Song S, Sun X, Ju J, Deng Y*. (2019) Efficacy of compounds isolated from Streptomyces olivaceus against the morphogenesis and virulence of Candida albicans. Mar Drugs 17(8). Pii: E442
12. Meng L#, Zhao H#, Zhao S#, Sun X, Zhang M*, and Deng Y*. (2019) Inhibition of yeast-to-hypha transition and virulence of Candida albicans by 2-alkylaminoquinoline derivatives. Antimicrob Agents Chemother 63(4). Pii: e01891-18.
13. Cui C#, Song S#, Yang C#, Sun X, Huang Y, Li K, Zhao S, Zhang Y, Deng Y*. (2019) Disruption of quorum sensing and virulence in Burkholderia cenocepacia by a small molecule mimic of the cis-2-dodecenoic acid (BDSF) signal. Appl Environ Microbiol 85(8). Pii: e00105-19.
14. Zhong Y, Yan M, Jiang J, Zhang Z, Huang J, Min X, Zhang L, Deng Y*, Zhou X*, and He F* (2019). Mycophenolic acid inhibited the dimorphic switch of Sporisorium scitamineum by targeting ammonium transporter Ssa2. J Agric Food Chem 67:112-119.
15. Zhang C, Lv M, Yin W, Dong T, Chang C, Miao Y, Jia Y, and Deng Y*. (2019) Xanthomonas campestris promotes diffusible signal factor (DSF) biosynthesis and pathogenicity by utilizing glucose and sucrose from host plants. Mol Plant Microbe Interact 32:157-166.
16. Zhao S#, Huang JJ#, Sun X#, Huang X, Fu S, Yang L, Liu XW, He F*, and Deng Y*. (2018) (1-aryloxy-2-hydroxypropyl)-phenylpiperazine derivatives suppress Candida albicans virulence by interfering with morphological transition. Microbiol Biotech. 11(6): 1080-1089.
17. Cui C#, Yang C#, Song S#, Fu S, Sun X, Yang L, He F, Zhang LH, Zhang Y, and Deng Y*. (2018) A novel two-component system modulates quorum sensing and pathogenicity in Burkholderia cenocepacia. Mol Microbiol. 108:32-44.
18. Yang C#, Cui C#, Ye Q, Kan J, Fu S, Song S, Huang Y, He F, Zhang LH, Jia Y, Gao Y, Harwood CS*, and Deng Y*. (2017) Burkholderia cenocepacia integrates cis-2-dodecenoic acid and cyclic dimeric guanosine monophosphate to control virulence. Proc. Natl. Acad. Sci. U.S.A. 114:13006-13011.
