中山大学“百人计划” 青年研究员、博士生导师。2012年7月博士毕业于中科院上海有机化学研究所，师从翟宏斌教授和朱仕正研究员。随后加入贝勒医学院药理学与化学生物学系从事博士后研究，合作导师为Jin Wang 教授，并先后任研究助理，助理教授；2022年5月全职加入中山大学药学院（深圳），任课题组组长。以第一作者或共同第一作者在J. Am. Chem. Soc.、Nat. Commun.、Angew. Chem. Int. Ed. 及Proc. Natl. Acad. Sci .等期刊上发表论文多篇。
电子邮箱
chenjw353@mail.sysu.edu.cn
学科专业
药物化学，化学生物学，药理学
个人经历
学习经历
2001.09 – 2005.07 河北科技大学 本科
2007.09 – 2012.07 中科院上海有机化学研究所 博士
科研工作经历
2006.02 – 2007.08 北京先先科创化学有限公司 研发员
2012.07 – 2016.12 美国贝勒医学院 博士后
2016.12 – 2018.10 美国贝勒医学院 研究助理
2018.10 – 2022.04 美国贝勒医学院 助理教授
2022.05 – 中山大学药学院·深圳 青年研究员
研究方向
（1）靶向抗癌药物研究
（2）发展新颖生物正交反应及其应用
（3）构建基于天然产物的片段化合物库及其应用
（4）基于活性天然产物为分子探针的化学生物学研究
科研项目
中山大学百人计划 2022.05-2025.05 主持人
代表论著
1.Jianwei Chen, Peng Gao, Fangmiao Yu, Yang Yang, Shizheng Zhu, Hongbin Zhai*, “Total Synthesis of (+/-)-Merrilactone A”, Angewandte Chemie International Edition, 2012, 51, 5897-5899. (IF: 16.823)
2.Jianwei Chen, Mingkun Zhao, Fude Feng, Antons Sizovs, and Jin Wang*, “Tunable Thioesters as “Reduction” Responsive Functionality for Traceless Reversible Protein PEGylation”, Journal of the American Chemical Society, 2013, 135, 10938-10941. (IF: 16.383)
3.Jianwei Chen†, Xiqian Jiang†, Shaina L. Carroll, Jia Huang, Jin Wang*, "Theoretical and Experimental Investigation of Thermodynamics and Kinetics of Thiol-Michael Addition Reactions: A Case Study of Reversible Fluorescent Probes for Glutathione Imaging in Single Cells", Organic Letters, 2015, 17, 5978-5981. † contributed equally. (IF: 6.072)
4.Xianzhou Song†, Jianwei Chen†, Mingkun Zhao, Chengwei Zhang, Yang Yu, David M. Lonard, Dar-Chone Chow, Timothy Palzkill, Jianming Xu, Bert W. O’Malley*, Jin Wang*, “Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3”, Proceedings of the National Academy of Sciences, 2016, 113, 4970-4975. † contributed equally. (IF: 12.779)
5.Jianwei Chen†, Mingkun Zhao†, Xiqian Jiang, Antons Sizovs, Meng C Wang, Christopher R Provost, Jia Huang, Jin Wang, “Genetically anchored fluorescent probes for subcellular specific imaging of hydrogen sulfide”, Analyst, 2016, 141, 1209-1213. † contributed equally. (IF: 5.227)
6.Xiqian Jiang†, Jianwei Chen†, Aleksandar Bajić, Chengwei Zhang, Xianzhou Song, Shaina L. Carroll, Zhao-Lin Cai, Meiling Tang, Mingshan Xue, Ninghui Cheng, Christian P. Schaaf, Meng C. Wang, Mirjana Maletić-Savatić, Jin Wang*, “Quantitative Real-Time Imaging of Glutathione”, Nature Communications, 2017, 8, 16087. † contributed equally. (IF: 17.694)
7.Jianwei Chen†, Xiqian Jiang†, Chengwei Zhang, Kevin MacKenzie, Fabio Stossi, Timothy Palzkill, Meng Wang, Jin Wang*, “A Reversible Reaction-Based Fluorescent Probe for Real-Time Imaging of Glutathione Dynamics in Mitochondria”, ACS Sensors, 2017, 2, 1257-1261. † contributed equally. (IF: 9.618)
8.JiangXiqian Jiang†, Chengwei Zhang†, Jianwei Chen†, Sungwoo Choi, Ying Zhou, Mingkun Zhao, Xianzhou Song, Xi Chen, Mirjana Maletić-Savatić, Timothy Palzkill, David Moore, Meng C. Wang, and Jin Wang*, “Quantitative Real-Time Imaging of Glutathione with Subcellular Resolution”, Antioxidants & Redox Signaling, 2018, doi.org/10.1089/ars.2018.7605. † contributed equally. (IF: 7.468)
9.Li Qin†, Jianwei Chen†, Dong Lu†, Prashi Jain, Yang Yu, David Cardenas, Xiaohui Peng, Xiaobin Yu, Jianming Xu, Jin Wang*, Bert W O’Malley*, David M Lonard*, “Development of improved SRC-3 inhibitors as breast cancer therapeutic agents”, Endocrine-Related Cancer, 2021, 28, 657-670.† contributed equally. (IF: 5.900)
10.Yang Yang, Xingnian Fu, Jianwei Chen, Hongbin Zhai*, “Total Synthesis of (-)-Jiadifenin”, Angewandte Chemie International Edition, 2012, 51, 9825-9828. (IF: 16.823)
11.Antons Sizovs, Xianzhou Song, M. Neal Waxham, Yilong Jia, Fude Feng, Jianwei Chen, Amanda Wicker, Yan Yu, and Jin Wang*, “Precisely Tunable Engineering of Sub-30 nm Monodisperse Oligonucleotide Nanoparticles”, Journal of the American Chemical Society, 2014, 136, 234-240. (IF: 16.383)
12.Xiqian Jiang, Yong Yu, Jianwei Chen, Mingkun Zhao, Hui Chen, Xianzhou Song, Alexander J. Matzuk, Shaina L. Carroll, Xiao Tan, Antons Sizovs, Ninghui Cheng, Meng C. Wang, and Jin Wang*, “Quantitative Imaging of Glutathione in Live Cells Using a Reversible Reaction-Based Ratiometric Fluorescent Probe”, ACS Chemical Biology, 2015, 10, 864-874. (IF: 4.634)
13.Xianzhou Song, Chengwei Zhang, Mingkun Zhao, Hui Chen, Xing Liu, Jianwei Chen, David M. Lonard, Li Qin, Jianming Xu, Xiaosong Wang, Feng Li, Bert W. O’Malley*, Jin Wang*, "Steroid Receptor Coactivator-3 (SRC-3/AIB1) as a Novel Therapeutic Target in Triple Negative Breast Cancer and Its Inhibition with a Phospho-Bufalin Prodrug", PLoS ONE, 2015, 10, e0140011. (IF: 3.752)
14.Xiqian Jiang, Lingfei Wang, Shaina Laufer Carroll, Jianwei Chen, Meng C Wang, Jin Wang*, “Challenges and Opportunities for Small Molecule Fluorescent Probes in Redox Biology Applications”, Antioxidants and Redox Signaling, 2018, doi.org/10.1089/ars.2017.7491. (IF: 7.468)
15.Wen-Hao Guo†, Xiaoli Qi†, Xin Yu, Yang Liu, Chan-I Chung, Fang Bai, Xingcheng Lin, Dong Lu, Lingfei Wang, Jianwei Chen, Lynn Hsiao Su, Krystle J Nomie, Feng Li, Meng C Wang, Xiaokun Shu, José N Onuchic, Jennifer A Woyach, Michael L Wang, Jin Wang*, “Enhancing intracellular accumulation and target engagement of PROTACs with reversible covalent chemistry”, Nature communications, 2020, 11, 4268.† contributed equally. (IF: 17.694)
16.Xiqian Jiang, Jianwei Chen, Meng C Wang, Jin Wang*, “Glutathione quantification in live cells with real-time imaging and flow cytometry”, STAR protocols,2020, 1, 100170. (IF: 7.468)
17.Lingfei Wang, Feng Jin, Xiqian Jiang, Jianwei Chen, Meng C Wang, Jin Wang*, “Fluorescent Probes and Mass Spectrometry-Based Methods to Quantify Thiols in Biological Systems”, Antioxidants and Redox Signaling, 2022, 36, 354-365. (IF: 7.468)
会议墙报及演讲
1. The 11th Annual Dan L. Duncan Cancer Center Symposium, Houston,TX, November 12, 2015. Poster: Tunable Thioesters as “Reduction” Responsive Functionality for Traceless Reversible Protein PEGylation
2.The 25th Anniversary of the Bioorganic Chemistry Gordon Research Conference, Andover, NH, June 5–10, 2016.
Poster: Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3
3. The 2017 High-Throughput Chemistry and Chemical Biology (HTCCB) Gordon Research Conference,Andover, NH, June 25–30, 2017.
Poster: Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3
4.中国化学会第十一届全国有机化学学术会议，上海，2019年8月31日–2019年9月3日。
口头报告：Quantitative Real-Time Imaging of Glutathione
