郭腾飞，2018年于德国慕尼黑工业大学获博士学位，目前担任深圳湾实验室特聘研究员，北京大学深圳研究生院博士生导师，课题组长，中山大学（深圳）药学院校外博士生导师。广东省杰出青年基金(2022年)和深圳优秀青年基金（2022年）获得者。近五年来，以第一作者/通讯作者在AD领域权威期刊Alzheimer’s & Dementia (2018, 2022)、Biological Psychiatry (2021)、Annals of Neurology (2022)、Neurology (2020a, 2020b, 2023)、Journal of Nuclear Medicine (2017)、Alzheimer’s Research & Therapy (2020a, 2020b, 2023)、Translational Psychiatry (2022)等杂志发表多篇原创学术文章，其中独立通讯作者12篇，对于理解AD病理特征的发病机制和演化规律具有重要的科学意义和临床价值，长期担任Alzheimer’s & Dementia、Nature Communications等杂志审稿人。曾多次受邀参加国际学术会议口头汇报最新研究进展，获得美国阿尔茨海默协会“Young Investigator”荣誉奖，目前担任国际阿尔茨海默ISTAART协会“提升青年科学家小组”执行委员会亚洲主管。

 

电子邮箱：tengfei.guo@pku.edu.cn

 

个人经历

工作经历：

1.2021年10月至今：北京大学深圳研究生院助理教授，博士生导师

2.2020年12月至今：深圳湾实验室特聘研究员，课题组长

3.2018年5至2020年11月：加州大学伯克利分校，博士后

教育经历：

1.2014年11月至2018年4月：德国慕尼黑工业大学，医学生命科学与技术，博士

2.2013年9月至2014年9月：德国海德堡大学，医科物理学，理学硕士

3.2011年9月至2013年9月：上海交通大学，生物医学工程，硕士

4.2007年9月至2011年6月：四川大学，医学信息工程，学士

 

研究方向

阿尔茨海默病的发病机制及早期诊疗、大脑神经影像、生物标志物、神经调节

 

科研项目

1.项目名称: 阿尔茨海默病临床前阶段的风险因素及演化规律, 广东省杰出青年基金(批准号：2023B1515020113), 2023-2026, 在研（支配额度100万），负责人

2.项目名称: 阿尔茨海默病的突触功能障碍, 深圳市优秀青年基金(批准号：RCYX20221008092935096), 2023-2026, 在研（支配额度200万），负责人

3.项目名称：血浆磷酸化tau蛋白升高在Aβ阴性老年痴呆神经退行性病变中的作用及机制研究，国家自然科学基金面上项目(批准号：82171197)，2022-2025，在研（支配额度55万），负责人

4.项目名称：阿尔茨海默病的发病机制及早期诊断研究，深圳湾实验室自主立项重大项目培育项目(批准号：S211101002-2)，2021-2022年，结题（支配额度150万），子课题负责人

5.项目名称：高通量阿尔茨海默症脑类器官芯片应用系统研发，深圳湾实验室开放基金项目(批准号：SZBL2020090501014)，2020-2023年，在研（支配额度100万），联合负责人

 

代表论著

期刊论文

  • Jing Du#, Anqi Li#, Dai Shi#, Xuhui Chen, Qingyong Wang, Zhen Liu, Kun Sun, Tengfei Guo*. “Association of APOE4, osteoarthritis, β-amyloid, and tau accumulation in primary motor and somatosensory regions in Alzheimer's Disease”, Neurology, 2023 (Accepted).
  • Guoyu Lan and Tengfei Guo*, Reply to: “Aberrant GAP43 Gene Expression Is Alzheimer Disease Pathology-Specific”. Annals of Neurology, 2023, 93: 1049-1049.
  • Yue Cai, Jing Du, Anqi Li, Yalin Zhu, Linsen Xu, Kun Sun, Shaohua Ma, Tengfei Guo*. “Initial levels of β-amyloid and tau deposition have distinct effects on longitudinal tau accumulation in Alzheimer's disease”, Alzheimer’s Research & Therapy, 2023, 15 (30).
  • Guoyu Lan, Anqi Li, Zhen Liu, Shaohua Ma, Tengfei Guo*. “Presynaptic membrane protein dysfunction occurs prior to neurodegeneration and predicts faster cognitive decline”, Alzheimer’s & Dementia, 2022 (In press, DOI: 10.1002/alz.12890).
  • Guoyu Lan, Yue Cai, Anqi Li, Zhen Liu, Shaohua Ma, Tengfei Guo*. “Association of presynaptic loss with Alzheimer’s disease and cognitive decline”, Annals of Neurology, 2022, 92(6), 1001-1015.
  • Dai Shi, Siwei Xie, Anqi Li, Qingyong Wang, Hongbo Guo, Ying Han, Huaxi Xu, Wen-Biao Gan, Lei Zhang, Tengfei Guo*. “APOE-ε4 modulates the association among plasma Aβ42/Aβ40, vascular diseases, neurodegeneration and cognitive decline in non-demented elderly adults”. Translational Psychiatry, 2022, 12(1): 1-9.
  • Chenyang Jiang, Qingyong Wang, Siwei Xie, Zhicheng Chen, Liping Fu, Qiyu Peng, Ying Liang, Hongbo Guo, Tengfei Guo*. “β-amyloid discordance of cerebrospinal fluid and PET imaging shows distinct spatial tau patterns.” Brain Communications, 2022, 4(2): fcac084.
  • Tengfei Guo* Susan M. Landau, and William J. Jagust. “Age, vascular disease, and Alzheimer’s disease pathologies in amyloid negative elderly adults.” Alzheimer’s Research & Therapy, 2021, 13(1): 1-12.
  • Lexin Li*, Chengchun Shi, Tengfei Guo, and William J. Jagust. “Sequential pathway inference for multimodal neuroimaging analysis.” Stat (2021): e433.
  • Yoon Bora*, Tengfei Guo, Karine Provost, Deniz Korman, Tyler J. Ward, Susan M. Landau, William J. Jagust. “Abnormal tau in amyloid PET negative individuals.” Neurobiology of Aging, 2021, 109:125-134.
  • Tengfei Guo*, Deniz Korman, Suzanne L. Baker, Susan M. Landau, William J. Jagust, “Longitudinal cognitive and biomarker measurements support a unidirectional pathway in Alzheimer’s Disease pathophysiology”. Biological Psychiatry, 2021, 89:786–794.
  • Tengfei Guo*, Deniz Korman, Renaud La Joie, Leslie M. Shaw, John Q. Trojanowski William J. Jagust, Susan M. Landau, “Normalization of CSF pTau measurement by Aβ40 improves its performance as a biomarker of Alzheimer’s disease.” Alzheimer’s Research & Therapy, 2020, 12(1): 1-15.
  • Tengfei Guo*, Leslie M. Shaw, John Q. Trojanowski William J. Jagust, Susan M. Landau, “Association of CSF Aβ, amyloid PET and cognition in cognitively unimpaired elderly adults”. Neurology, 2020, 95(15): e2075-e2085.
  • Tengfei Guo*, Susan M. Landau, William J. Jagust, “Detecting earlier stages of amyloid deposition using PET in cognitively normal elderly adults”. Neurology, 2020, 94 (14): e1512-e1524.
  • Tengfei Guo*, Juergen Dukart, Matthias Brendel, Axel Rominger, Timo Grimmer, Igor Yakushev, “Rate of β-amyloid accumulation varies with baseline amyloid burden: Implications for anti-amyloid drug trials”. Alzheimer’s & Dementia, 2018, 14(11): 1387-1396.
  • Tengfei Guo#, Matthias Brendel#, Timo Grimmer, Axel Rominger#, IgorYakushev#, *, “Prediction of regional beta-amyloid accumulation by baseline amyloid PET in Alzheimer’s disease”. Journal of Nuclear Medicine, 2017, 58(4): 639-645.
  • Tengfei Guo, Hangdao Li, Yifan Lv, Hongyang Lu, Jinhai Niu, Junfeng Sun, Guo-Yuan Yang, Chuancheng Ren*, Shanbao Tong*. Neuroprotective pulsed transcranial ultrasound stimulation in stroke after distal middle cerebral artery occlusion. IEEE Transactions on Biomedical Engineering, 62.10 (2015): 2352-2357.

会议论文

  • Guoyu Lan, Yue Cai, Anqi Li, Zhen Liu, Tengfei Guo, for the Alzheimer’s Disease Neuroimaging Initiative. “Elevated CSF GAP43 is driven by tau aggregation rather than β-amyloid and neurodegeneration in Alzheimer’s disease”. Alzheimer’s Association International Conference 2022, July 30-August 4, 2022, visually.
  • Yue Cai, Shaohua Ma, Tengfei Guo, for the Alzheimer’s Disease Neuroimaging Initiative. “Baseline β-amyloid and tau predict longitudinal tau accumulation at different stages of Alzheimer’s disease”.Alzheimer’s Association International Conference 2022, July 30-August 4, 2022, visually.
  • Anqi Li, Jing Du, Yue Cai, Tengfei Guo, for the Alzheimer’s Disease Neuroimaging Initiative. “Weight increases and decreases show distinct association with Alzheimer's Disease in different age and APOE-ε4 status”.Alzheimer’s Association International Conference 2022, July 30-August 4, 2022, visually.
  • Tengfei Guo*, Susan M. Landau, William J. Jagust, for the Alzheimer’s Disease Neuroimaging Initiative. “CSF p-Tau/Aβ40 ratio predicts longitudinal hypometabolism and cognitive decline in amyloid negative elderly adults”(Oral presentation).Alzheimer’s Association International Conference 2021, July 26-30, 2021, visually.
  • Dai Shi, Lei Zhang, Tengfei Guo, for the Alzheimer’s Disease Neuroimaging Initiative. “High precision plasma Aβ42/Aβ40 ratio detects early amyloid deposition in non-demented elderly adults”.Alzheimer’s Association International Conference 2021, July 26-30, 2021, visually.
  • Tengfei Guo*, Deniz Korman, Renaud La Joie, Leslie M. Shaw, John Q. Trojanowski William J. Jagust, Susan M. Landau, for the Alzheimer’s Disease Neuroimaging Initiative. “CSF p-Tau/Aβ40 adjusts for the variance of CSF production and predicts brain tau accumulation in Alzheimer’s disease”.Alzheimer’s Association International Conference 2020, July 27-31, 2020, visually.
  • Tengfei Guo*, Susan M. Landau, William J. Jagust, for the Alzheimer’s Disease Neuroimaging Initiative. “CSF p-Tau detects cerebral tau accumulation earlier than tau PET in amyloid positive elderly adults”. The 14th Human Amyloid Imaging, Miami, Florida, January 16-18, 2020.
  • Tengfei Guo*, Susan M. Landau, William J. Jagust, for the Alzheimer’s Disease Neuroimaging Initiative.“Longitudinal amyloid, neurodegeneration and cognition in predementia elderly individuals with different ATN profiles”(Oral presentation). Alzheimer’s Association International Conference 2019, Los Angeles, Jul 14-18, 2019.
  • Tengfei Guo*, Susan M. Landau, William J. Jagust, for the Alzheimer’s Disease Neuroimaging Initiative. “Detecting earlier stages of amyloid deposition using positron emission tomography in cognitively normal elder adults” (Oral presentation). The 13th Human Amyloid Imaging, Miami, Florida, January 16-18, 2019.
  • Tengfei Guo, Matthias Brendel; Timo Grimmer; Axel Rominger; Igor Yakushev. “Baseline amyloid PET predicts spatial pattern of beta-amyloid accumulation over time” (Oral presentation). The Society of Nuclear Medicine & Molecular Imaging (SNMMI) 2016 Annual Meeting, June 11-15, 2 San Diego.

荣誉及奖励：

  • 广东省杰出青年基金（2023年）
  • 深圳市优秀青年基金（2023年）
  • 深圳市海外高层次人才（2021年）
  • 国际阿尔茨海默协会年度会议(AAIC)“Young Investigator Travel Scholarship”（2023年）
  • 美国阿尔茨海默协会“Young Investigator”荣誉奖（2020年）
  • 美国Human amyloid imaging年度会议“Young Investigator Travel Scholarship”（2020年）
  • 国际核医学与分子影像协会“Alavi-Mandell Publication Award”奖 （2018年）