中山大学药学院（深圳）“百人计划”教授、博士生导师，药物化学教研室主任。

  百千万人才工程国家级人选、国家有突出贡献中青年专家、享受国务院政府特殊津贴专家和国家优青基金获得者；获中国抗癌协会青年科学家奖、中国免疫学会青年学者奖、中国国际多肽会“Young Peptide Scientist Award”和中国多肽产业十年成就奖—基础科学奖等荣誉，获国家发明专利授权30余项，部分专利成果已成功转化。

电子邮箱：

gaoyf29@mail.sysu.edu.cn

 

研究方向：

主要从事肿瘤免疫治疗新靶点发现、多肽药物筛选与设计、多肽疫苗设计和多肽口服递送等交叉领域研究；致力于解决多肽药物领域的共性关键技术，开发肿瘤免疫诊疗新策略。

科研项目：

  1. 深圳市重点项目（JCYJ20241202130045054），2025.03-2028.03，主持
  2. 深圳市医学研究专项（D2403007），2025.01-2027.12，主持
  3. 中山大学高校基本科研业务费-重大项目培育和新兴交叉学科培育计划项目（24xkjc021），2024.01-2026.12，主持
  4. 广东省粤深联合基金重点项目（2022B1515120085），2022.10-2025.09，主持
  5. 国家自然科学基金-区域创新发展联合基金重点项目（U20A20369），2021.01-2024.12，主持
  6. 广东省引进创新团队项目（2019ZT08Y464），2020.07.01-2025.06.30，核心成员
  7. 深圳市高层次人才团队项目（KQTD20190929173853397），2020.07.30-2025.07.31，核心成员
  8. 中山大学高校基本科研业务费-青年教师重点培育项目（19ykzd29），2019.01-2020.12，主持
  9. 国家自然科学基金-优秀青年科学基金项目（81822043），2019.01-2021.12，主持
  10. 国家自然科学基金-河南联合基金重点项目（U1604286），2017.01-2020.12，主持

 

代表论著：

  1. Xiuman Zhou#, Youmei Xiao#, Yanfeng Gao*. Challenges and opportunities for lysosome-targeting chimeras. Cell Reports Physical Science, 2025, 6(8):102778. (Invited)
  2. Xiao Y, He Z, Li W, Chen D, Niu X, Yang X, Zeng W, Wang M, Qian Y, Su Y, Luo F, Chen G, Liu J, Sui X, Zhou X*, Gao Y*. A covalent peptide-based lysosome-targeting protein degradation platform for cancer immunotherapy. Nat Commun. 2025 Feb 6;16(1):1388.  (Featured Article)
  3. Li W, Yang X, Wang M, Hu Z, Chen S, Sui X, Chen D, Niu X, Liu J, Xiao Y, Zhou X, Chen G*, Gao Y*. Development of a Cascade-Targeting Oral Vaccine via Glycoprotein 2 on Intestinal Microfold Cells for Cancer Immunotherapy. Nano Lett. 2025 Apr 2;25(13):5165-5173. (Cover Story)
  4. Zheng J#, Wang M#, Pang L#, Wang S, Kong Y, Zhu X, Zhou X, Wang X, Chen C, Ning H, Zhao W, Zhai W, Qi Y, Wu Y*, Gao Y*. Identification of a novel DEC-205 binding peptide to develop dendritic cell-targeting nanovaccine for cancer immunotherapy. J Control Release. 2024 Sep;373:568-582. 
  5. Zhu, X., Wang, X., Liu, Z., Jiang, B., He, Z., Liu, S., Wu, Y., Wu, Z., Zhang, T., Liu, M., Li, K., Niu, X., Gao, Y*. Peroxidase-Like Nanozyme Activates the cGAS-STING Pathway via ROS-InducedmtDNA Release for Cancer Immunotherapy(2024) Advanced Functional Materials, 34, 2401576.
  6. Qian, Y., Sun, Y., Shi, P., Zhou, X., Zhang, Q., Dong, Q., Jin, S., Qiu, L., Niu, X., Zhou, X., Zhao, W., Wu, Y., Zhai, W. *, Gao, Y*. Development of LAG-3/FGL1 blocking peptide and combination with radiotherapy for cancer immunotherapy(2024) Acta Pharmaceutica Sinica B, 14 (3), pp. 1150-1165. 
  7. Yang, X., Li, W., Li, S., Chen, S., Hu, Z., He, Z., Zhu, X., Niu, X., Zhou, X., Li, H., Xiao, Y., Liu, J., Sui, X., Chen, G. *, Gao, Y*. Fish oil-based microemulsion can efficiently deliver oral peptide blocking PD-1/PD-L1 and simultaneously induce ferroptosis for cancer immunotherapy(2024) Journal of Controlled Release, 365, pp. 654-667. 
  8. Niu, X., Wu, M., Li, G., Zhou, X., Cao, W., Zhai, W., Wu, A., Zhou, X., Jin, S., Chen, G., Li, Y., Du, J., Wu, Y., Qiu, L., Zhao, W. *, Gao, Y*. Identification and optimization of peptide inhibitors to block VISTA/PSGL-1 interaction for cancer immunotherapy(2023) Acta Pharmaceutica Sinica B, 13 (11), pp. 4511-4522. (Cover Story)
  9. Hu, Z., Li, W., Chen, S., Chen, D., Xu, R., Zheng, D., Yang, X., Li, S., Zhou, X., Niu, X., Xiao, Y., He, Z., Li, H., Liu, J., Sui, X. *, Gao, Y*. Design of a novel chimeric peptide via dual blockade of CD47/SIRPα and PD-1/PD-L1 for cancer immunotherapy(2023) Science China Life Sciences, 66 (10), pp. 2310-2328. 
  10. Shen, W., Shi, P., Dong, Q., Zhou, X., Chen, C., Sui, X., Tian, W., Zhu, X., Wang, X., Jin, S., Wu, Y., Chen, G., Qiu, L., Zhai, W. *, Gao, Y*. Discovery of a novel dual-targeting D-peptide to block CD24/Siglec-10 and PD-1/PD-L1 interaction and synergize with radiotherapy for cancer immunotherapy(2023) Journal for ImmunoTherapy of Cancer, 11 (6), e007068. 
  11. Chen C, Sui X, Ning H, Sun Y, Du J, Chen X, Zhou X, Chen G, Shen W, Pang L, Zhou X, Shi R, Li W, Wang H, Zhao W, Zhai W, Qi Y, Wu Y*, Gao Y*. Identification of natural product 3, 5-diiodotyrosine as APOBEC3B inhibitor to prevent somatic mutation accumulation and cancer progression. J Immunother Cancer. 2022 Nov;10(11):e005503. 
  12. Shi Ranran, Li Yubing, Ran Ling, Dong Yu, Zhou Xiuman, Tang Jingwen, Han Lu, Wang Mingshuang, Pang Liwei, Qi Yuanming, Wu Yahong*, Gao Yanfeng*. Screening and identification of HLA-A2-restricted neoepitopes for immunotherapy of non-microsatellite instability-high colorectal cancer. Sci China Life Sci. 2022, 65(3): 572-587.
  13. Gou S, Liu W, Wang S, Chen G, Chen Z, Qiu L, Zhou X, Wu Y, Qi Y, Gao Y*. Engineered Nanovaccine Targeting Clec9a+ Dendritic Cells Remarkably Enhances the Cancer Immunotherapy Effects of STING Agonist. Nano Lett. 2021, 21(23): 9939-9950. (Cover Story)
  14. Shanshan Gou, Shuai Wang, Wenwen Liu, Guanyu Chen, Dongyang Zhang, Jiangfeng Du, Zhongyi Yan, Hongfei Wang, Wenjie Zhai, Xinghua Sui, Yahong Wu, Yuanming Qi and Yanfeng Gao*. Adjuvant-free peptide vaccine targeting Clec9a on dendritic cells can induce robust antitumor immune response through Syk/IL-21 axis. Theranostics, 2021, 11(15):7308-7321.
  15. Wanqiong Li#, Xueqin Zhu#, Xiuman Zhou, Xiaoxi Wang, Wenjie Zhai, Bingyu Li, Jiangfeng Du, Guodong Li, Xinghua Sui, Yahong Wu, Mingxia Zhai, Yuanming Qi, Guanyu Chen*, Yanfeng Gao*. An orally available PD-1/PD-L1 blocking peptide OPBP-1-loaded trimethyl chitosan hydrogel for cancer immunotherapy. J Control Release. 2021,334:376-388.
  16. Wenjie Zhai, Xiuman Zhou, Mingxia Zhai, Wanqiong Li, Yunhui Ran, Yixuan Sun, Jiangfeng Du, Wenshan Zhao, Lingxiao Xing, Yuanming Qi*, Yanfeng Gao*. Blocking of the PD-1/PD-L1 interaction by a novel cyclic peptide inhibitor for cancer immunotherapy. Sci China Life Sci. 2021, 64(4):548-562
  17. Xiuman Zhou#, Chao Zuo#, Wanqiong Li, Weiwei Shi, Xiaowen Zhou, Hongfei Wang, Shaomeng Chen, Jiangfeng Du, Guanyu Chen, Wenjie Zhai, Wenshan Zhao, Yahong Wu, Yuanming Qi, Lei Liu*, Yanfeng Gao*. A novel D-peptide identified by mirror-image phage display blocks TIGIT/PVR for cancer immunotherapy. Angew Chem Int Ed. 2020, 59(35): 15114-8. (VIP paper)
  18. Hongfei Wang, Yixuan Sun, Xiuman Zhou, Chunxia Chen, Ling Jiao, Wanqiong Li, Shanshan Gou, Yanying Li, Jiangfeng Du, Guanyu Chen, Wenjie Zhai, Yahong Wu, Yuanming Qi, Yanfeng Gao*. CD47/Sirpα blocking peptide identification and synergistic effect with irradiation for cancer immunotherapy. J ImmunoTher Cancer. 2020, 8:e000905.
  19. Wenjie Zhai, Xiuman Zhou, Hongfei Wang, Wanqiong Li, Guanyu Chen, Xinghua Sui, Guodong Li, Yuanming Qi*, Yanfeng Gao*. A novel cyclic peptide targeting LAG-3 for cancer immunotherapy by activating antigen-specific CD8+ T cell responses. Acta Pharm Sin B. 2020, 10(6):1047-1060.
  20. Haonan Chang, Beiyuan Liu, Yun-kun Qi, Yang Zhou, Yanping Chen, Kammai Pan, Wenwen Li, Xiuman Zhou, Weiwei Ma, Caiyun Fu, Yuanming Qi, Lei Liu*, Yanfeng Gao*. Blocking of the PD-1/PD-L1 Interaction by a D-Peptide Antagonist for Cancer Immunotherapy. Angew Chem Int Ed, 2015, 54(40):11760-11764.