博士,百人计划副教授。2007年于兰州大学化学系(国家理科基地)获得学士学位,2014年于兰州大学获得博士学位(导师:王锐院士,张绪穆教授),主要从事药物导向的手性功能分子高效合成与修饰研究。近年来利用协同催化等策略发展新颖高效的催化体系(例如基于拟酶催化发展了原创性的ZhaoPhos配体),并成功应用于多种重要手性药物(前体)的高效绿色合成和生物活性分子的改造。目前在Acc. Chem. Res., Nature Comm.,Angew. Chem. Int. Ed.Chem. Sci.Org. Lett.Org. Chem. Front.等期刊上发表高水平论文二十余篇。主持在研国家自然科学青年基金和深圳市基金项目,参与多项国家自然科学基金。

网页

https://orcid.org/0000-0001-8259-4321

电子邮箱

zhaoqy26@mail.sysu.edu.cn;qingyang.zhao@hotmail.com

个人经历

教育背景

2003-2007年兰州大学理学学士(化学国家理科基地)

2007-2014年兰州大学-  Rutgers University (New Brunswick) 联合培养博士

工作经历

2016-2017年香港理工大学Postdoctoral Fellow(应用生物与化学科学系)

2017-2018年香港中文大学Research Associate(化学系)

2019-至今中山大学药学院(深圳)(药学)

 

研究方向

基于生命物质转化的化学本质,以手性药物和多肽药物的合成与修饰为导向,发展新颖高效的催化体系并用于手性分子的多样性构建,实现生物活性分子/药物(先导化合物)的精准合成、化合物库的构建以及功能研究。

承担本科生课程

《有机化学》(课程负责人)、《有机化学实验》(课程负责人)

《药物化学实验》(参与),《仪器分析》(参与)

科研项目

2020-2023 深圳市科创委面上项目(竞争性项目)

2021-2022 中央高校基本科研经费-青年教师团队项目

2020-2021 中央高校基本科研经费-青年教师培育项目

2019-2020 中山大学百人计划启动经费

2017-2019 国家自然科学基金青年项目

 

代表论著

1.Zhao, Qingyang;  Li, Shengkun;  Huang, Kexuan;  Wang, Rui*; Zhang, Xumu*; A Novel Chiral Bisphosphine-Thiourea Ligand for Asymmetric Hydrogenation of beta,beta-Disubstituted Nitroalkenes, Org. Lett.201315, 4014

2.Zhao, Qingyang;  Wen, Jialin;  Tan, Renchang;  Huang, Kexuan;  Metola, Pedro;  Wang, Rui*;  Anslyn, Eric V.*; Zhang, Xumu*; Rhodium-Catalyzed Asymmetric Hydrogenation of Unprotected NH Imines Assisted by a Thiourea, Angew. Chem. Int. Ed.201453, 8467

3.Dong, Xiu-Qin*;  Zhao, Qingyang;  Li, Pan;  Chen, Caiyou; Zhang, Xumu*; Metalorganocatalysis: cooperating transition-metal catalysis and organocatalysis through a covalent bond, Org. Chem. Front.20152, 1425

4.Li, Pan#;  Zhou, Ming#;  Zhao, Qingyang;  Wu, Weilong;  Hu, Xinquan;  Dong, Xiu-Qin*; Zhang, Xumu*; Synthesis of Chiral beta-Amino Nitroalkanes via Rhodium-Catalyzed Asymmetric Hydrogenation, Org. Lett.201618, 40

5.Wen, Jialin;  Tan, Renchang;  Liu, Shaodong;  Zhao, Qingyang*; Zhang, Xumu*; Strong Bronsted acid promoted asymmetric hydrogenation of isoquinolines and quinolines catalyzed by a Rh-thiourea chiral phosphine complex via anion binding, Chem. Sci.20167, 3047

6.Fu, Wai Chung;  Zheng, Bin;  Zhao, Qingyang;  Chan, Wesley Ting Kwok; Kwong, Fuk Yee*; Cascade Amination and Acetone Monoarylation with Aryl Iodides by Palladium/Norbornene Cooperative Catalysis, Org. Lett.201719, 4335

7.Han, Zhengyu;  Guan, Yu-Qing;  Liu, Gang;  Wang, Rui;  Yin, Xuguang;  Zhao, Qingyang;  Cong, Hengjiang;  Dong, Xiu-Qin*; Zhang, Xumu*; Iridium-Catalyzed Asymmetric Hydrogenation of Tetrasubstituted alpha-Fluoro-beta-enamino Esters: Efficient Access to Chiral alpha-Fluoro-beta-amino Esters with Two Adjacent Tertiary Stereocenters, Org. Lett.201820, 6349

8.Yang, Qingjing;  Choy, Pui Ying;  Zhao, Qingyang;  Leung, Man Pan;  Chan, Hoi Shan;  So, Chau Ming;  Wong, Wing-Tak; Kwong, Fuk Yee*; Palladium-Catalyzed N-Arylation of Sulfoximines with Aryl Sulfonates, J. Org. Chem.201883, 11369

9.Yin, Xuguang;  Huang, Yi;  Chen, Ziyi;  Hu, Yang;  Tao, Lin;  Zhao, Qingyang;  Dong, Xiu-Qin*; Zhang, Xumu*; Enantioselective Access to Chiral 2-Substituted 2,3-Dihydrobenzo 1,4 dioxane Derivatives through Rh-Catalyzed Asymmetric Hydrogenation, Org. Lett.201820, 4173

10.Zhao, Qingyang;  Fu, Wai Chung*; Kwong, Fuk Yee*; Palladium-Catalyzed Regioselective Aromatic Extension of Internal Alkynes through a Norbornene-Controlled Reaction Sequence, Angew. Chem. Int. Ed.201857, 3381

11.Sun, Huai-Ri#;  Zhao, Qingyang#;  Yang, Hui;  Yang, Sen;  Gou, Bo-Bo;  Chen, Jie; Zhou, Ling*; Chiral Phosphoric-Acid-Catalyzed Cascade Prins Cyclization, Org. Lett.201921, 7143

12.Kou, Xun#;  Zhao, Qingyang#; Guan, Zheng-Hui*; Copper-catalyzed asymmetric dearomative alkynylation of isoquinolines, Org. Chem. Front.20207, 829

13.Sun, Yongjie#;  Zhao, Qingyang#;  Wang, Heng;  Yang, Tilong;  Wen, Jialin*; Zhang, Xumu*; Asymmetric Hydrogenation of Cationic Intermediates for the Synthesis of ChiralN,O-Acetals, Chem. Eur. J.202026, 11470 (封面)

14.Tao, Lin;  Zhao, Qingyang;  Zhang, Xumu*; Dong, Xiu-Qin*; Facile access to chiral 4-substituted chromanes through Rh-catalyzed asymmetric hydrogenation, Chin. Chem. Lett.202031, 1859

15.Zhao, Qingyang#*;  Chen, Caiyou#;  Wen, Jialin;  Dong, Xiu-Qin*; Zhang, Xumu*; Noncovalent Interaction-Assisted Ferrocenyl Phosphine Ligands in Asymmetric Catalysis, Acc. Chem. Res.202053, 1905 (封面)

16.Wong, Shun Man;  Choy, Pui Ying;  Zhao, Qingyang;  Yuen, On Ying;  Yeung, Chung Chiu;  So, Chau Ming; Kwong, Fuk Yee*; Design of Benzimidazolyl Phosphines Bearing Alterable P,O or P,N-Coordination: Synthesis, Characterization, and Insights into Their Reactivity, Organometallics202140, 2265

17.Yang, Pengfei;  Zhang, Yaodu;  Chen, Ming;  Zhao, Qingyang;  Ren, Zhi-Hui*; Guan, Zheng-Hui*; Rhodium-Catalyzed Enantioselective and Desymmetrizative Pauson–Khand Reaction: Access to Tricyclo[6.2.1.04,11]undecenes, Org. Lett.202123, 9241

18.Zhao, Qingyang*;  Choy, Pui Ying;  Li, Luguang; Kwong, Fuk Yee*; Recent explorations of palladium-catalyzed regioselective aromatic extension processes, Tetrahedron Lett.202162, 152670 (封面)

19.Sun, Ying-Ying;  Zhang, Bin;  Yu, Liangbin;  Cui, Ranran;  Zhao, Qingyang*; Zhang, Qing-Wei*; Rhodium catalyzed asymmetric synthesis of Chiraphos derivatives, Chin. Chem. Lett.202233, 5084

20.Yu, Liangbin;  Junjun Liu;  Xiang, Shiyu;  Lu, Taotao;  Ma, Ping; Zhao, Qingyang*; Silver-Catalyzed Direct Nucleophilic Cyclization: Enantioselective De Novo Synthesis of C-C Axially Chiral 2-Arylindoles, Org. Lett.202325, 522

21.Zhao, Qingyang#;  Yu, Le#;  Zhang, Yao-Du#;  Guo, Yong-Qiang;  Chen, Ming;  Ren, Zhi-Hui; Guan, Zheng-Hui*; C(alkyl)–C(vinyl) bond cleavage enabled by Retro-Pallada-Diels-Alder reaction, Nat. Commun.202314, 2572

22.Xiang, Shiyu;  Lu, Taotao;  Liu, Junjun; Zhao, Qingyang*; Redox Transformation of β-Sulfinyl Esters for Asymmetric Synthesis of Sulfone-Based Axially Chiral Styrenes, Org. Chem. Front.2023, 10.1039/D3QO00932G (2023热点论文)