教授、博导，中山大学“百人计划”引进人才，药剂学学术带头人，广东省精准医学应用学会纳米医学分会副主委，广东省特支计划科技创新青年拔尖人才，深圳市海外高层次人才（孔雀计划）和深圳市高层次领军人才。2011年博士毕业于南开大学化学学院；2012~2014年在清华大学深圳国际研究生院从事生物学博士后研究；2014年在清华大学深圳国际研究生院担任讲师；2017-2018年在新加坡南洋理工大学做访问学者；2017年11月加入中山大学。长期从事药剂学、生物医用材料、药物递送系统等领域的研究。近年来，以第一/通讯作者在Nature Communications、Science Advances、Advanced Functional Materials、Biomaterials 、ACS Nano、Acta Pharmaceutica Sinica B和 Journal of Controlled Release等国际知名期刊发表SCI收录论文70余篇。他引次数累积12000余次，个人H-index 62。10篇论文入选为ESI高被引论文，2篇论文入选为ESI热点论文，多篇论文被选为封面或封底论文。申请国家发明专利15项，授权12项。主持或主持完成国家自然科学基金、广东特支计划科技创新青年拔尖人才项目、广东省自然科学基金等国家和省部级项目10余项。荣获深圳市青年科技奖、中华医学科技奖和华夏医学科技奖等奖励，并连续入选全球前2%顶尖科学家榜单（World’s Top 2% Scientists，2020-2026年度）和“全球顶尖前10万科学家排名”。Advanced Materials、Matter、Nature Communications、Biomaterials、Journal of Controlled Release等国际知名期刊的长期受邀审稿专家。获得Acta Biomaterialia和International Journal of Pharmaceutics等多个Elsevier期刊“杰出审稿人”(Outstanding Reviewer)荣誉称号。担任国际知名期刊Chinese Chemical Letters、Smart Materials in Medicine和Pharmaceutics编委、Acta Pharmaceutica Sinica B和Asian Journal of Pharmaceutical Sciences青年编委及Frontiers in Bioengineering and Biotechnology客座主编。

电子邮箱

zengxw23@mail.sysu.edu.cn orxwzeng@163.com

学科专业

药剂学

教育与工作经历

2006年9月-2011年6月     南开大学, 化学学院, 高分子化学与物理博士

2012年3月-2014年3月     清华大学, 深圳国际研究生院, 生物学博士后

2014年3月-2017年11月   清华大学, 深圳国际研究生院, 讲师

2017年4月-2018年4月     新加坡南洋理工大学，访问学者

2017年11月-2025年3月   中山大学，药学院（深圳），副教授/博导

2025年3月 - 至今             中山大学，药学院（深圳），教授/博导

授课课程

《药剂学》、《药剂学实验》、《药用高分子材料》

研究方向

药剂学、生物材料和药物递送系统

代表性学术论文

[1] Dan Zhang, Anxian Chen, Haimeng Huang, Wenjing Li, Qili Huang, Hongzhong Chen, Jiaxing Zhang, Li Yang*, Caijun Sun*, Xiaowei Zeng*, Stimulate-and-retain hydrogel strategy integrating oncolytic virus and oxaliplatin for dual ICD-inducing antitumor immunity, Acta Pharmaceutica Sinica B 2026 https://doi.org/10.1016/j.apsb.2026.07.040

[2] Wenjing Li, Dan Zhang, Haimeng Huang, Rongchen Zou, Ziyang Zhang, Ping Sun, Hongzhong Chen, Li Yang*, Shaoyun Jiang*, Xiaowei Zeng*, Versatile Microneedle Platform for Localized Immunomodulatory Therapy of Periodontitis Targeting the Reactive Oxygen Species/NF-κB Pathway, ACS Nano 20 (2026) 12833-12849

[3] Yao Yang, Ping Huang, Qian Li, Jinyuan Li, Wenyan Wang, Jiachan Lin, Ping Sun, Guangsheng Du, Hongzhong Chen*, Xun Sun*, Xiaowei Zeng*, Urate-responsive hydrogel microneedles with rapid bubble separation for simplified long-term gout management, Journal of Controlled Release 389 (2026) 114491.

[4] Wenyan Wang, Shun-Yu Yao, Jingjing Luo, Chendi Ding, Qili Huang, Yao Yang, Zhaoqing Shi, Jiachan Lin, Yu-Chen Pan, Xiaowei Zeng*, Dong-Sheng Guo*, Hongzhong Chen*,Hypoxia-responsive albumin nanoparticles-mediated mitophagy regulation for cascaded oxidative stress therapy of hypoxic tumors, Nature Communications 16 (2025) 596.ESI高被引论文

[5] Zimu Li, Zirui Chen, Kexin Shi, Ping Huang, Wenfeng Zeng, Qili Huang, Jingwen Peng, Li Yang, Hongzhong Chen*, Yanli Zhao*, Xiaowei Zeng*, Polyphenol-Based Self-Assembled Nanomedicine for a Three-Pronged Approach to Reversing Tumor Immunosuppression, Advanced Healthcare Materials 14 (2025) 2402127

[6] Yao Yang, Xiaotong Liang, Qimanguli Saiding, Jiachan Lin, Jinyuan Li, Wenyan Wang, Ping Huang, Li Huang, Wenfeng Zeng, Jinhai Huang, Hongzhong Chen*, Wei Tao*, Xiaowei Zeng*, Light-activated polymeric crosslinked nanocarriers as a checkpoint blockade immunoregulatory platform for synergistic tumor therapy, Materials Today 80 (2024) 012.

[7] Qili Huang, Chendi Ding, Wenyan Wang, Li Yang, Yinglong Wu, Wenfeng Zeng, Zimu Li, Zhaoqing Shi, Lin Mei, Xiaowei Zeng*, Yanli Zhao*, Hongzhong Chen*, An “AND” logic gate-based supramolecular therapeutic nanoplatform for combatting drug-resistant non-small cell lung cancer, Science Advances 10 (2024) eadp9071.

[8] Wenfeng Zeng, Zimu Li, Qili Huang, Chendi Ding, Li Yang, Wenyan Wang, Zhaoqing Shi, Yao Yang, Hongzhong Chen*, Lin Mei*, Xiaowei Zeng*, Multifunctional Mesoporous Polydopamine-Based Systematic Delivery of STING Agonist for Enhanced Synergistic Photothermal-Immunotherapy, Advanced Functional Materials 34 (2024) 2307241

[9] Ping Sun, Zimu Li, Dan Zhang, Wenfeng Zeng, Yi Zheng, Lin Mei, Hongzhong Chen*, Nansha Gao*, Xiaowei Zeng*, Multifunctional biodegradable nanoplatform based on oxaliplatin prodrug cross-linked mesoporous polydopamine for enhancing cancer synergetic therapy, Chinese Chemical Letters 35 (2024) 108346 (Cover Paper)

[10] Li Yang, Yiwen Gao, Qingyun Liu, Wenjing Li, Zimu Li, Dan Zhang, Rixin Xie, Yi Zheng,* Hongzhong Chen,* and Xiaowei Zeng*, A Bacterial Responsive Microneedle Dressing with Hydrogel Backing Layer for Chronic Wound Treatment, Small 20 (2024) 2307104 

[11] Li Yang, Dan Zhang, Wenjing Li, Hongbing Lin, Chendi Ding, Qingyun Liu, Liangliang Wang, Zimu Li, Lin Mei, Hongzhong Chen*, Yanli Zhao*, Xiaowei Zeng*，Biofilm Microenvironment Triggered Self-Enhancing Photodynamic Immunomodulatory Microneedle for Diabetic Wound Therapy, Nature Communications 14 (2023) 7658. ESI高被引论文

[12] Minchao Li, Li Yang, Congcong Wang, Mingting Cui, Ziyu Wen, Zhiheng Liao, Zirong Han, Yangguo Zhao, Bing Lang, Hongzhong Chen, Jun Qian, Yuelong Shu*, Xiaowei Zeng*, and Caijun Sun*, Rapid Induction of Long-Lasting Systemic and Mucosal Immunity via Thermostable Microneedle-Mediated Chitosan Oligosaccharide-Encapsulated DNA Nanoparticles, ACS Nano 17 (2023) 24200-24217

[13] Ping Huang, Yao Yang, Wenyan Wang, Zimu Li, Nansha Gao, Hongzhong Chen, Xiaowei Zeng*, Self-driven nanoprodrug platform with enhanced ferroptosis for synergistic photothermal-IDO immunotherapy, Biomaterials 299 (2023) 122157.ESI高被引论文

[14] Zimu Li, Li Yang, Dan Zhang, Wenyan Wang, Qili Huang, Qingyun Liu, Kexin Shi, Yongkang Yu, Nansha Gao*, Hongzhong Chen, Shaoyun Jiang, Zhongjian Xie*, Xiaowei Zeng*, Mussel-inspired “plug-and-play” hydrogel glue for postoperative tumor recurrence and wound infection inhibition, Journal of Colloid and Interface Science 650 (2023) 1907-1917 

[15] Dan Zhang, Zimu Li, Li Yang, Hualin M*, Hongzhong Chen*, Xiaowei Zeng*,Architecturally designed sequential-release hydrogels, Biomaterials 303 (2023) 122388.

[16] Yao Yang, Zimu Li, Ping Huang, Jiachan Lin, Jinyuan Li, Kexin Shi, Jiahui Lin, Jingwen Hu, Zhuoxian Zhao, Yongkang Yu, Hongzhong Chen, Xiaowei Zeng*, Lin Mei*，Rapidly separating dissolving microneedles with sustained-release colchicine and stabilized uricase for simplified long-term gout management, Acta Pharmaceutica Sinica B 13 (2023) 3454-3470

[17] Li Yang, Qingyun Liu, Xinhui Wang, Nansha Gao, Xiuzhen Li, Hongzhong Chen, Lin Mei*, Xiaowei Zeng*, Actively Separated Microneedle Patch for Sustained-Release of Growth Hormone to Treat Growth Hormone Deficiency, Acta Pharmaceutica Sinica B 13 (2023) 344-358.ESI高被引论文

[18] Yongkang Yu, Qinzhen Cheng, Xiaoyuan Ji, Hongzhong Chen, Wenfeng Zeng, Xiaowei Zeng*, Yanli Zhao*, Lin Mei*. Engineered drug-loaded cellular membrane nanovesicles for efficient treatment of post-surgical cancer recurrence and metastasis, Science Advances 8 (2022) eadd3599.ESI高被引论文

[19] Zimu Li, Yao Yang, Huaxuan Wei, Xiaoting Shan, Xuanzhi Wang, Meitong Ou, Qingyun Liu, Nansha Gao, Hongzhong Chen, Lin Mei*, Xiaowei Zeng* , Charge-reversal biodegradable MSNs for tumor synergetic chemo/ photothermal and visualized therapy, Journal of Controlled Release 338 (2021) 719-730. ESI高被引论文

[20] Wei Cheng, Xiaowei Zeng*, Hongzhong Chen, Zimu Li, Wenfeng Zeng, Lin Mei, Yanli Zhao*, Versatile Polydopamine Platforms: Synthesis and Promising Applications for Surface Modification and Advanced Nanomedicine, ACS Nano 13 (2019) 8537-8565.ESI高被引论文