副教授（PI）。中山大学“百人计划”人才引进，广东省“珠江人才计划”青年拔尖人才，深圳市高层次“鹏城孔雀计划”特聘岗位。于四川大学华西药学院获药剂学硕士学位，沈阳药科大学获药剂学博士学位。2012年-2017年在中科院上海药物研究所制剂中心工作，曾任副研究员；2017年-2020年先后在美国康涅狄格大学和佐治亚理工学院任博士后和研究科学家（Research scientist I），2020年11月加入中山大学药学院（深圳）。近年来在PNAS，Science Robotics，J Controlled Release，Advanced Functional Materials，Biomaterials，Pharmaceutical Research，Euro J Pharm Sci 等国际权威刊物上发表研究论文40余篇。科研成果曾被《Scientific American》、《Nature Biotechnology》等世界知名科技新闻媒体报道。主持国家自然科学基金面上项目、青年基金，中山大学人才启动项目，广东省自然基金，中科院自主部署项目，中国博士后基金等项目。参与多项新药和创新制剂的临床转化研究，其中3项已进入临床研究。申请美国专利和PCT专利2项，中国专利3项，曾在美国获200万美元风险投资。曾荣获“中国科学院青年创新促进会会员”，“赛洛菲-中科院上海生科院优秀青年人才”称号。任European Journal of Pharmaceutics and Biopharmaceutics、Asian Journal of pharmaceutical Science 杂志编委；Journal of Controlled Release杰出审稿人。

 

电子邮箱：xiadn@mail.sysu.edu.cn

欢迎有志从事新型药物制剂、药物递送研究和产业转化的研究生、博士后加入本团队。

学科专业：药剂学

 

研究方向：

本团队致力于工业药剂学与生物药剂学前沿领域，采用高效低毒的药用材料、物理器件及生物医学工程交叉技术在药物与疫苗递送中的创新应用。主要研究内容涵盖：

1）眼部、皮肤和消化道药物递送生物屏障关键机制研究及创新制剂开发；

2）核酸疫苗物理递送技术；

3）创新药械结合技术。

A diagram of a product AI-generated content may be incorrect.

 

讲授课程:《生物药剂学和药物动力学》理论和实验、《药剂学》、《高等药剂学》、《药物制剂设计策略和实例》、《现代生物制药》。

 

工作经历：

2020.11—今：中山大学药学院（深圳），副教授

2017—2020：美国佐治亚理工学院化学与分子生物工程系，博士后、研究科学家

2017—2017：美国康涅狄格大学药学系，博士后

2014—2017：中国科学院上海药物研究所制剂中心，副研究员

2012—2014：中国科学院上海药物研究所制剂中心，博士后

2011—2012：扬子江药业集团上海海尼药业有限公司，制剂组长

 

学习经历：

2008.09—2011.09：沈阳药科大学药学院，药剂学（国家重点学科），博士学位

（2011年1月—2011年6月，丹麦哥本哈根大学药学系联合培养）

2005.09—2008.07：四川大学华西药学院，药剂学（国家重点学科），硕士学位

2001.09—2005.07：湖南中医药大学药学院，药学，本科

 

国内外学术任职情况：

国家自然科学基金青年和面上项目函审专家

European Journal of Pharmaceutics and Biopharmaceutics 杂志编委

Asian Journal of pharmaceutical Science 杂志青年编委

10余个国际权威杂志特约审稿人，包括ACS Nano、Nature communication、Journal of Controlled Release、European Journal of Pharmaceutical Science、Molecular Pharmaceutics、International Journal of Pharmaceutics。

 

主要科研项目：

国家级项目

国家自然科学基金（面上），2026.1-2029.12，主持

国家自然科学基金（面上），2017.1-2020.12，主持

国家自然科学基金（青年基金），2013.1-2015.12，主持

中国博士后科学基金（特别资助），2014.1-2015.1，主持

中国博士后科学基金（一等资助），2013.7-2014.7，主持

省市级项目

广东省自然科学基金面上项目，2022-2025年，主持

深圳市稳定支持计划面上项目，2023-2026年，主持

中山大学高校基本科研业务费青年教师团队项目，2022-2022年，主持

中山大学“百人计划”启动项目，2021-2024年，主持

中国科学院自主部署项目，2016.9-2018.8，主持

参与的其它项目

NIH（R01AI143844），参与

Bill & Melinda Gates Foundation （OPP1164271），参与

国家自然科学基金委（面上项目），81373356，2014.1-2017.12，参与

中国科学院科研装备研制项目，YZ201244，2012.7-2014.7，参与

上海市“科技创新行动计划”基础研究重点项目，14JC1493200，2014.09-2017.08，参与

中科院药物创新研究院自主部署项目，CASIMM0120153020，2015.9-2017.8，参与

国家自然科学基金委（面上项目），81573378，2016.1-2019.12，参与

 

论文发表（按照时间顺序）

  1. Jinbin Liu, Huanglan Yang, Dengning Xia*. Polymer-free tacrolimus microsphere implants for long-acting prevention of corneal neovascularization in rats by subconjunctiva injection. Journal of Controlled Release, 2025, 385, 114043. (IF11.5). 
  2. Yulin Hou 1, Jiayin Yao 1, Jingwen Hu, Dengning Xia*. Inflammation-retentive hyaluronic acid-mesalamine conjugate for enhanced oral therapy in ulcerative colitis. International Journal of Biological Macromolecules, 2025, 318, 144949. (IF8.5). 
  3. Hongbing Lin, Jinbin Liu, Yulin Hou, Zhiyan Yu, Juan Hong, Jianghong Yu, Yu Chen, Jingwen Hu, Dengning Xia* Pure drug microneedle patch for transdermal delivery of liraglutide, Drug Delivery and Translational Research, 2025, 15: 216–230. (IF5.5). 
  4. Youkyung Choi, Grace Sanghee Lee, Song Li, Jeong Woo Lee, Tonya Mixson-Hayden, Jungreem Woo, Dengning Xia, Mark R. Prausnitz, Saleem Kamili, Michael A. Purdy, Rania A. Tohme. Hepatitis B vaccine delivered by microneedle patch: Immunogenicity in mice and rhesus macaques. Vaccine, 2023, 41: 3663-3672.
  5. Dengning Xia*, Cunde Hu, Yulin Hou. Regorafenib loaded self-assembled lipid-based nanocarrier for colorectal cancer treatment via lymphatic absorption. European Journal of Pharmaceutics and Biopharmaceutics, 2023, 185: 165-176. (IF4.3).
  6. Andrey Romanyuk, Ruixue Wang, Alexander Marin, Benjamin M Janus, Eric I Felner, Dengning Xia, Yenny Goez-Gazi, Kendra J Alfson, Abdul S Yunus, Eric A Toth, Gilad Ofek, Ricardo Carrion Jr, Mark R Prausnitz, Thomas R Fuerst, Alexander K Andrianov. Skin Vaccination with Ebola Virus Glycoprotein Using a Polyphosphazene-Based Microneedle Patch Protects Mice against Lethal Challenge. Journal of Functional Biomaterials, 2023, 14(1), 16. 
  7. Dengning Xia *, Amy J. Wood-Yang, Mark R. Prausnitz*. Clearing away barriers to oral drug delivery. Science Robotics, 2022, 7, eade331 (IF 27.541). 
  8. Dengning Xia, Randall Toy, Pallab Pradhan, Amir Hejri, Jeremy Chae, Hans E. Grossniklaus, Claus Cursiefen, Krishnendu Roy*, Mark R Prausnitz*. Enhanced immune responses to vaccine antigens in the corneal stroma. Journal of Controlled Release, 2023, 353: 434-446. (IF 11.467). 
  9. Dengning Xia, Rui Jin, Gaurav Byagathvalli, Huan Yu, Ling Ye, Chao-Yi Lu, M. Saad Bhamla*, Chinglai Yang* and Mark R Prausnitz*. An Ultra-Low-Cost Electroporator with Microneedle Electrodes (ePatch) for SARS-CoV-2 Vaccination. PNAS,2021118 (45) e2110817118.
  10. Song Li, Dengning Xia, Mark R. Prausnitz. Efficient Drug Delivery into Skin Using a Biphasic Dissolvable Microneedle Patch with Water-Insoluble Backing. Advanced Functional Materials, 2021, 2103359, 1-11. (IF18.808). 
  11. Yuan Liu, Dan Chen, Jialin Li, Dengning Xia，Yong Gan. NPC1L1‐Targeted Cholesterol‐Grafted Poly (β‐Amino Ester)/pDNA Complexes for Oral Gene Delivery. Advanced healthcare materials. 2019, 1800934 (1~12). (IF9.933).
  12. Dengning Xia *, Yuan He, Qiuxia Li, Cunde Hu, Wei Huang, Yunhai Zhang, Feng Wan, Chi Wang, Yong Gan*. Transport mechanism of lipid covered saquinavir pure drug nanoparticles in intestinal epithelium. Journal of Controlled Release, 2018, 269, 159–170. (IF 11.467). 
  13. Weiwei Fan, Dengning Xia, Quanlei Zhu, Xiuying Li, Shufang He, Chunliu Zhu, Shiyan Guo, Lars Hovgaard, Mingshi Yang, Yong Gan. Functional nanoparticles exploit the bile acid pathway to overcome multiple barriers of the intestinal epithelium for oral insulin delivery. Biomaterials, 2018, 151, 13-23. 
  14. Yan Wei, Yuxi Wang, Dengning Xia, Shiyan Guo, Feng Wang, Xinxin Zhang, Yong Gan. Thermosensitive Liposomal Co-delivery of HSA-paclitaxel and HSA-ellagic Acid Complexes for Enhanced Drug Perfusion and Efficacy Against Pancreatic Cancer. ACS Appl. Mater. Interfaces, 2017, 9 (30), pp 25138–25151. (IF9.229). 
  15. Qiuxia Li, Dengning Xia*, Jinsong Tao, Aijun Shen, Yuan He, Yong Gan, Chi Wang. Self- assembled core–shell-type lipid–polymer hybrid nanoparticles: intracellular trafficking and relevance for oral absorption. Journal of Pharmaceutical Sciences, 2017, 106 (10)3120-3130 (IF 3.534).
  16. Aijun Shen, Dengning Xia, Yong Gan, Juan Li*. Polyelectrolyte layer-by-layer assembled lipid nanoparticles for improving oral absorption of doxorubicin. Acta Pharmaceutica Sinica 2016, 51 (7): 1136−1143. 
  17. Weiwei Fan, Dengning Xia, Quanlei Zhu, Lei Hu, Yong Gan*. Intracellular transport of nanocarriers across the intestinal epithelium. Drug Discovery Today, 2016, 21 (5), 856-863. (IF 7.851). 
  18. Dengning Xia, Hongzhen Yu, Jinsong Tao, Jianrong Zeng; Quanlei Zhu, Chunliu Zhu, Yong Gan*. Supersaturated polymeric micelles for oral cyclosporine A delivery: The role of Soluplus-sodium dodecyl sulfate complex. Colloids and Surfaces B: Biointerfaces. 2016, 141, 301-310. (IF5.268). 
  19. Dengning Xia, Neha Shrestha, Jacco van de Streek, Huiling Mu, Mingshi Yang*. Optimization of Spray Drying of Fenofibrate Loaded Nanostructured Lipid Carriers. Asian Journal of Pharmaceutical Sciences. 2016, 11 (4), 507-515. (IF4.06). 
  20. Quanlei Zhu, Wenyi Song, Dengning Xia, Weiwei Fan, Miaorong Yu, Shiyan Guo, Chunliu Zhu, Yong Gan*. Poly-L-glutamic acid functionalized nanocomplex for improved oral drug absorption. Journal of Material Chemistry B, 2015,3, 8508-8517. (IF: 4.543)
  21. Yuan He, Dengning Xia, Qiuxia Li, Jin-song Tao, Yong Gan*, Chi Wang* Enhanced cellular uptake, transport, and oral absorption of saquinavir achieved by the use of a nanocrystal suspension. Acta Pharmacol. Sin., 2015, 36: 1151-1160. (IF6.150).
  22. Dengning Xia, Jinsong Tao, Yuan He, Quanlei Zhu, Miaorong Yu, Yong Gan*. Wheat germ agglutinin nanocage stabilized drug nanocrystals cross intestinal epithelium barrier via goblet cell. Journal of Controlled Release, 2015, 213, e25–e26. (IF7.705). 
  23. Quanlei Zhu, Xiuying Li, Dengning Xia, Hongzhen Yu, Dan Chen, Weiwei Fan, Yong Gan. Lipid- Based Formulations for Oral Drug Delivery: Effects on Drug Absorption and Metabolism. Curr Drug Metab. 2015; 16 (3):200-210. (IF:3.731).
  24. Dengning Xia, Jinsong Tao, Yuan He, Quanlei Zhu, Dan Chen, Miaorong Yu, Fude Cui, Yong Gan*. Enhanced Transport of Nanocage Stabilized Pure Nanodrug Across Intestinal Epithelial Barrier Mimicking Listeria Monocytogenes. Biomaterials 2015, 37, 320-332. (IF10.273). 
  25. Dengning Xia, Fude Cui, Yong Gan, Huiling Mu, Mingshi Yang*. Design of lipid matrix particles for fenofibrate: effect of polymorphism of glycerol monostearate on drug incorporation and release. Journal of pharmaceutical sciences.2014, 103(2)697-705. IF2.590. (IF3.007). 
  26. Dengning Xia, Yong Gan, Fude Cui*. Application of precipitation methods for the production of water-insoluble drug nanocrystals: production techniques and stability of nanocrystals. Current Pharmaceutical Design, 2014, 20(3):408-435. (IF3.452). 
  27. Nrupa Borkar, Dengning Xia, René Holm, Yong Gan, Anette Müllertz, Mingshi Yang, Huiling Mu*. Investigating the correlation between in vivo absorption and in vitro release of fenofibrate from lipid matrix particles in biorelevant medium. Eur J Pharm Sci 2014, 51, 204-210. (IF 3.756).
  28. Hongzhen Yu1, Dengning Xia1 (co-first author), Quanlei Zhu, Chunliu Zhu, Dan Chen, Yong Gan*. Supersaturated polymeric micelles for oral cyclosporine A delivery. Eur. J. Pharm. Biopharm 2013, 85(3)1325-1336. (IF4.159). 
  29. Quanlei Zhu, Tao Guo, Dengning Xia, Xiuying Li, Chunliu Zhu, Haiyan Li, Defang Ouyang, Jiwang Zhang, Yong Gan. Pluronic F127-modified liposome-containing tacrolimus-cyclodextrin inclusion complexes: improved solubility, cellular uptake and intestinal penetration. Journal of Pharmacy and Pharmacology. 2013, 65(8):1107-1117. (IF 2.405).
  30. Dan Chen, Dengning Xia, Xiuying Li, Quanlei Zhu, Hongzhen Yu, Chunliu Zhu, Yong Gan*. Comparative study of Pluronic® F127-modified liposomes and chitosan-modified liposomes for mucus penetration and oral absorption of cyclosporine A in rats. International Journal of Pharmaceutics, 2013, 11; 449(1-2):1-9. (IF 3.649).
  31. Dengning Xia, Mei Ouyang, Jian X. Wu, Yanbo Jiang, Hongyu Piao, Shaoping Sun, Li Zheng, Jukka Rantanen, Fude Cui*, Mingshi Yang. Polymer-mediated anti-solvent crystallization of nitrendipine: monodispersed spherical crystals and growth mechanism. Pharmaceutical Research, 2012, 29, 158-169. (IF4.742). 
  32. Dengning Xia, Jian X. Wu, Fude Cui*, Haiyan Qu, Thomas Rades, Jukka Rantanen, Mingshi Yang*. Solvent-mediated amorphous to crystalline transformation of nitrendipine in amorphous particle suspensions containing polymers. European Journal of Pharmaceutical Sciences. 2012, 46(5):446- 454. (IF3.350). 
  33. Jian X. Wu, Dengning Xia, Frans van den Berg, José Manuel Amigo, Thomas Rades, Mingshi Yang, Jukka Rantanen. A novel image analysis as a tool for online monitoring of nucleation and crystal growth during solid state phase transformations. International Journal of Pharmaceutics, 2012, 20; 433(1-2):60-70. (IF 5.875).
  34. Peng Quan, Kai Shi, Hongyu Piao, Hongzhe Piao, Na Liang, Dengning Xia, Fude Cui*. A novel surface modified nitrendipine nanocrystals with enhancement of bioavailability and stability. Int J Pharm. 2012, 430(1-2):366-371. (IF 3.649).
  35. Peng Quan, Dengning Xia, Hongze Piao, Hongyu Piao, Kai Shi, Yinnong Jia, Fude Cui*. Nitrendipine nanocrystals: its preparation, characterization, and in vitro-in vivo evaluation. AAPS PharmSciTech. 2011,12,1136-1143. (IF 3.246).
  36. Hongyu Piao, Mei Ouyang, Dengning Xia, Peng Quan, Wenhua Xiao, Yanzhi Song, Fude Cui*. In vitro-in vivo study of CoQ10-loaded lipid nanoparticles in comparison with nanocrystals. International Journal of Pharmaceutics, 2011, 419 (1-2):255-259. (IF5.875)
  37. Yanbo Jiang, Kai Shia, Dengning Xia, Hongze Piao, Peng Quan, Tao Song and Fude Cui*. Protamine modified metal ion–protein chelate microparticles for sustained release of interferon. International Journal of Pharmaceutics, 2011, 407(1-2):31-37. (IF5.875).
  38. Shaoping Sun, Na Liang, Yoshiaki Kawashima Dengning Xia, Fude Cui*. Hydrophobic ion pairing of an insulin-sodium deoxycholate complex for oral delivery of insulin. International Journal of Nanomedicine, 2011:6 3049–3056. (IF 6.400).
  39. Dengning Xia, Fude Cui*, Hongze Piao, Dongmei Cun, Hongyu Piao, Yanbo Jiang, Mei Ouyang, Peng Quan. Effect of crystal size on in vitro dissolution and oral absorption of nitrendipine in rats. Pharmaceutical Research, 2010, 27, 1965-1976. (IF4.742). 
  40. Dengning Xia, Peng Quan, Hongze Piao, Hongyu Piao, Shaoping Sun, Yongmei Yin, Fude Cui*. Preparation of stable nitrendipine nanosuspensions using the precipitation-ultrasonication method for enhancement of dissolution and oral bioavailability. European Journal of Pharmaceutical Sciences, 2010, 40, 325-334. (IF3.350). 
  41. Yanbo Jiang, Kai Shi, Dengning Xia, Shuo Wang, Tao Song, Fude Cui*. Protein spherulites for sustained release of interferon: preparation, characterization and in vivo evaluation. Journal of Pharmaceutical Sciences, 2010, 100(5): 1913-1922. (IF5.875).