电子邮箱

yuanpy3@mail.sysu.edu.cn

个人经历

2004年-2008年    中山大学 化学与化学工程学院，获学士学位；

2009年-2013年    新加坡国立大学 化学系，获博士学位；

2013年-2018年    新加坡国立大学 化学系，研究员；

研究方向

靶向药物控释；肿瘤及细菌感染的检测及治疗；纳米生物医学材料。

科研项目

1.  2022年高校基本科研业务费青年拔尖科研人才培育项目；角色：主持，状态：进行中；

2.  2021年深圳市面上项目；角色：主持，状态：进行中；

3.  2021年国家自然科学面上项目；角色：主持，状态：进行中；

4.  2020年深圳市面上项目；角色：主持，状态：进行中；

5. 2020年国家自然科学青年基金项目；角色：主持，状态：进行中；

6. 2019年高校基本科研业务费中山大学青年教师培育项目；角色：主持，状态：已结题；

7. 中山大学“百人计划“启动基金；角色：主持，状态：已结题。

代表论著

1. P.Y. Yuan⁺,* F. Yang⁺, S. S. Liew⁺, J.C. Yan, X. Dong, J.F. Wang, S.B. Du, X. Mao, L.Q. Gao, S. Q. Yao*, “Intracellular Co-Delivery of Native Antibody and siRNA for Combination Therapy by Using Biodegradable Silica Nanocapsules”, Biomaterials, 2022, 281, 121376.

2. C.N. Li⁺, Z.S. Li⁺, Y.Y. Gan⁺, F.L. Jiang, H.M. Zhao, J. Tan, Y. Y. Yang*, P.Y. Yuan*, X. Ding*, “Selective Capture, Separation, and Photothermal Inactivation of Methicillin-Resistant Staphylococcus aureus (MRSA) Using Functional Magnetic Nanoparticles”, ACS Appl. Mater. Interfaces, 2022, DOI:10.1021/acsami.1c24102.

3. Y.X. Yu⁺, H.M. Zhao⁺, J.Y. Lin, Z.S. Li, G.B. Tian, Y. Y. Yang*, P.Y. Yuan*, X. Ding*, “Repurposing Non-Antibiotic Drugs Auranofin and Pentamidine in Combination to Combat Multidrug-Resistant Gram-Negative Bacteria”, Int. J. Antimicrob. Agents, 2022, 106582.

4. S. Wu, Y. Huang, J.C. Yan, Y.Z. Li, J.F. Wang, Y. Y. Yang*, P.Y. Yuan*, X. Ding*, “Bacterial Outer Membrane-Coated Mesoporous Silica Nanoparticles for Targeted Delivery of Antibiotic Rifampicin against Gram-Negative Bacterial Infection In Vivo”, Adv. Funct. Mater., 2021, 31, 2103442.

5. C.N. Li⁺, Z.S. Li⁺, Y.X. Zeng, X.S. Cao, H.M. Zhao, Y. Y. Yang*, P.Y. Yuan*, X.H. Lu*, X. Ding*, “Co₃O₄ Nanowires Capable of Discharging Low Voltage Electricity Showing Potent Antibacterial Activity for Treatment of Bacterial Skin Infection”, Adv. Healthc. Mater., 2022, 11, 2102044.

6. Y.Y. Gan⁺, C.N. Li⁺, X.R. Peng, S. Wu, Y.Z. Li, J. P. K. Tan, Y. Y. Yang*, P.Y. Yuan*, X. Ding*, “Fight Bacteria with Bacteria: Bacterial Membrane Vesicles as Vaccines an Delivery Nanocarriers against Bacterial Infections”, Nanomed.-Nanotechnol., 2021, 35, 102398.

7. P.Y. Yuan⁺,* X. Mao⁺, S. S. Liew, S. Wu, Y. Huang, L. Li, S. Q. Yao*, “Versatile Multiplex Endogenous RNA Detection with Simultaneous Signal Normalization Using Mesoporous Silica Nanoquenchers”, ACS Appl. Mater. Interfaces, 2020, 12, 57695-57709. 

8. X. Ding⁺*, H.M. Zhao⁺, Y.Z. Li, A. L. Lee, Z.S. Li, M.J. Fu, C.N. Li, Y. Y. Yang*, P.Y. Yuan*, “Synthetic Peptide Hydrogels as 3D Scaffolds for Tissue Engineering.” Adv. Drug Deliver. Rev., 2020, 160, 78-104.

9. Y.Z. Li, Y.Y. Gan, C.N. Li, Y. Y. Yang,* P.Y. Yuan,* X. Ding*, “Cell Membrane-Engineered Hybrid Soft Nanocomposites for Biomedical Applications”, J. Mater. Chem. B, 2020, 8, 5578-5596.

10. P.Y. Yuan, X. Mao, X.F. Wu, S. S. Liew, L. Li, S. Q. Yao, “Mitochondria-Targeting Intracellular Delivery of Native Proteins by Using Biodegradable Silica Nanoparticles”, Angew. Chem. Int. Ed., 2019, 58, 7657-7661.

11. X. Mao⁺, P.Y. Yuan⁺,* C.M. Yu, L. Li, S. Q. Yao,* “Nanoquencher-Based Selective Imaging of Protein Glutathionylation in Live Mammalian Cells”, Angew. Chem. Int. Ed. 2018, 57, 10257-10262. (VIP paper)（+共同第一作者，*共同通讯作者）

12. P.Y. Yuan, X. Ding, Y. Y. Yang, Q.-H. Xu, “Metal Nanoparticles for Diagnosis and Therapy of Bacterial Infection”, Adv. Healthc. Mater. 2018, 7, 1701392. 

13. P.Y. Yuan, H.L. Zhang, L.H. Qian, X. Mao, S.B. Du, C.M. Yu, B. Peng, S. Q. Yao, “Intracellular Delivery of Functional Native Antibodies under Hypoxic Conditions by Using a Biodegradable Silica Nanoquencher”, Angew. Chem. Int. Ed. 2017, 56, 12481-12485. 

14. P.Y. Yuan, X. Mao, K. C. Chong, J.Q. Fu, S.J. Pan, S.Z. Wu, C.M. Yu, S. Q. Yao, “Simultaneous Imaging of Endogenous Survivin mRNA and On-Demand Drug Release in Live Cells by Using a Mesoporous Silica Nanoquencher”, Small, 2017, 13, 1700569. 

15. X. Ding⁺, P.Y. Yuan⁺, N.Y. Gao, H. Zhu, Y. Y. Yang, Q.-H. Xu, “Au-Ag Core-shell Nanoparticles for Simultaneous Bacterial Imaging and Synergistic Antibacterial Activity”, Nanomed.-Nanotechnol. 2017, 13, 297-305. (+共同第一作者)

16. P.Y. Yuan, R.Z. Ma, Q.-H. Xu, “Highly Sensitive and Selective Two-Photon Sensing of Cartap Using Au@Ag Core-Shell Nanoparticles”, Sci. China Chem. 2016, 59, 78-82. 

17. P.Y. Yuan, R.Z. Ma, N.Y. Gao, M. Garai, Q.-H. Xu, “Plasmon Coupling-Enhanced Two-Photon Photoluminescence of Au@Ag Core-shell Nanoparticles and Applications in Nuclease Assay”, Nanoscale, 2015, 7, 10233-10239. 

18. P.Y. Yuan⁺, X. Ding⁺, Z.P. Guan, N.Y. Gao, Y. Y. Yang, Q.-H. Xu, “Plasmon‐Coupled Gold Nanospheres for Two‐Photon Imaging and Photoantibacterial Activity”, Adv. Healthc. Mater., 2015, 4, 674-678.（+共同第一作者）

19. P.Y. Yuan, R.Z. Ma, Z.P. Guan, N.Y. Gao, Q. H. Xu, “Tuning Two photon Photoluminescence of Gold Nanoparticle Aggregates with DNA and Its Application as Turn on Photoluminescence Probe for DNA Sequence Detection”, ACS Appl. Mater. Interfaces, 2014, 6, 13149-13156. 

20. P.Y. Yuan, Y.H. Lee, M.K. Gnanasammandhan, Z.P. Guan, Y. Zhang, Q.-H. Xu, “Plasmon Enhanced Upconversion Luminescence of NaYF₄:Yb,Er@SiO₂@Ag Core-shell Nanocomposites for Cell Imaging”, Nanoscale, 2012, 4, 5132-5137. (ESI高被引论文)