中山大学“百人计划”引进人才，教授、博士生导师，入选深圳高层次人才、中山大学逸仙学者。博士毕业于新加坡国立大学化学系，毕业后留任研究员，于2018年加入中山大学药学院（深圳）。从事药剂学、生物材料、化学生物学等领域的研究。以第一/通讯作者在J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Sci. Adv.、 ACS Nano、Adv. Funct. Mater.、Adv. Sci., Adv. Drug Deliv. Rev.等发表论文30余篇。

 

电子邮箱

yuanpy3@mail.sysu.edu.cn

 

个人经历

2004年-2008年    中山大学 化学与化学工程学院，获学士学位；
2009年-2013年    新加坡国立大学 化学系，获博士学位；
2013年-2018年    新加坡国立大学 化学系，研究员；
2018年-2024年    中山大学，副教授/博导；
2024年-至今         中山大学，教授/博导

 

研究方向

药物递送；生物材料；蛋白活性调控

 

科研项目

1. 2025年深圳医学研究专项；角色：主持，状态：进行中；
2. 2025年深圳市科创委面上项目；角色：主持，状态：进行中；
3. 2024年深圳市科创委面上项目；角色：主持，状态：进行中；
4. 2022年高校基本科研业务费青年拔尖科研人才培育项目；角色：主持，状态：结题；
5. 2021年深圳市面上项目；角色：主持，状态：结题；
6. 2021年国家自然科学面上项目；角色：主持，状态：结题；
7. 2020年深圳市面上项目；角色：主持，状态：结题；
8. 2020年国家自然科学青年基金项目；角色：主持，状态：结题；
9. 2019年高校基本科研业务费中山大学青年教师培育项目；角色：主持，状态：结题；
10. 中山大学“百人计划“启动基金；角色：主持，状态：结题。

 

代表论著

  1. J. Sun+, M.X. Gu+, L.Y. Peng, J. Guo, P. Chen, Y.L. Wen, F. Feng, X.J. Chen, T.Z. Liu, Y.H. Chen, X.Y. Lu*, L.Q. Gao*, S. Q. Yao*, P.Y. Yuan*, A Self-Assembled Nano-Molecular Glue (Nano-mGlu) Enables GSH/H2O2- Triggered Targeted Protein Degradation in Cancer Therapy, J. Am. Chem. Soc., 2025, 147, 372-383.
  2. X.R. Peng, J.Y. Chen, Y.Y. Gan, L. Yang, Y.J. Luo, C.X. Bu, Y. Huang, X.H. Chen, J. Tan, Y. Y. Yang*, P.Y. Yuan*, X. Ding*, Biofunctional Lipid Nanoparticles for Precision Treatment and Prophylaxis of Bacterial Infections, Sci. Adv., 2024, 10: eadk9754.
  3. P.Y. Yuan, X. Mao, X.F. Wu, S. S. Liew, L. Li*, S. Q. Yao*, Mitochondria-Targeting Intracellular Delivery of Native Proteins by Using Biodegradable Silica Nanoparticles, Angew. Chem. Int. Ed., 2019, 58, 7657-7661.
  4. X. Mao+, P.Y. Yuan+*, C.M. Yu, L. Li, S. Q. Yao*, Nanoquencher-Based Selective Imaging of Protein Glutathionylation in Live Mammalian Cells, Angew. Chem. Int. Ed. 2018, 57, 10257-10262. (VIP paper) 
  5.  P.Y. Yuan, H.L. Zhang, L.H. Qian, X. Mao, S.B. Du, C.M. Yu, B. Peng, S. Q. Yao*, Intracellular Delivery of Functional Native Antibodies under Hypoxic Conditions by Using a Biodegradable Silica Nanoquencher, Angew. Chem. Int. Ed. 2017, 56, 12481-12485. 
  6. J.Y. Chen, C.X. Bu, Y.T. Lu, X.R. Peng, J.Y. Yu, X. Ding*, P.Y. Yuan*, S. Hong*, Bioresponsive nanoreactor initiates cascade reactions for tumor vascular normalization and lactate depletion to augment immunotherapy, Biomaterials, 2025, 317, 123100.
  7. Y.Z. Li+, C. Li+, J.C. Yan, Y. Liao, C.Y. Qin, L.Y. Wang, Y. Huang, C. Yang, J.W. Wang*, X. Ding*, Y. Y. Yang*, P.Y. Yuan*, Polymeric Micellar Nanoparticles for Effective CRISPR/Cas9 Genome Editing in Cancer, Biomaterials, 2024, 309, 122573.
  8. J.C. Yan+, J.Y. Yu+, C.X. Bu, L. Yang, J.Y. Chen, X. Ding, P.Y. Yuan*, Antibiotic-Augmented Chemodynamic Therapy for Treatment of Helicobacter pylori Infection in the Dynamic Stomach Environment, Nano Lett., 2024, 24, 14983-14992.
  9. J.Y. Yu, Z.H. Guo, J.C. Yan, C.X. Bu, C. Peng, C.E. Li, R. Mao, J, Zhang, Z. Wang, S. Chen, M.C. Yao, Z.Y. Xie, C. Yang, Y. Y. Yang*,P.Y. Yuan*, Xin Ding*, Gastric Acid‐Responsive ROS Nanogenerators for Effective Treatment of Helicobacter pylori Infection without Disrupting Homeostasis of Intestinal Flora,Adv. Sci., 2023, 10, 2206957.
  10. H.M. Zhao+, L.-L. Zhong+, C. Yang+, N. Tang, Y.W. He, W. He, Z.H. Zhao, C.B. Wu, P.Y.  Yuan*, Y. Y. Yang*, G.-B. Tian*, X. Ding*, Antibiotic–Polymer Self-Assembled Nanocomplex to Reverse Phenotypic Resistance of Bacteria toward Last-Resort Antibiotic Colistin, ACS Nano, 2023, 17, 15411-15423.
  11. Z.Y. Cao, P.Y. Li, Y.Z. Li, M.J. Zhang, M. Hao, W.W. Li, X.L. Mao, L.J. Mo, C. Yang, X. Ding; Y. Y. Yang, P.Y. Yuan*, S.T. Shi*, X.X. Kou*, Encapsulation of Nano-Bortezomib in Apoptotic Stem Cell-Derived Vesicles for the Treatment of Multiple Myeloma, Small, 2023, 19, 2301748.
  12. C.Y. Qin+, N. Tang+, Y.Y. Gan, H.M. Zhao, Y. Li, G.B. Tian, Y. Y. Yang*, P.Y. Yuan*, X. Ding*, Liposomes Co-Delivering Curcumin and Colistin to Overcome Colistin Resistance in Bacterial Infections, Adv. Healthcare Mater., 2023, 12, 2202903.
  13. P.Y. Yuan+*, F. Yang+, S. S. Liew+, J.C. Yan, X. Dong, J.F. Wang, S.B. Du, X. Mao, L.Q. Gao, S. Q. Yao*, Intracellular Co-Delivery of Native Antibody and siRNA for Combination Therapy by Using Biodegradable Silica Nanocapsules, Biomaterials, 2022, 281, 121376.
  14. S. Wu, Y. Huang, J.C. Yan, Y.Z. Li, J.F. Wang, Y. Y. Yang*, P.Y. Yuan*, X. Ding*, Bacterial Outer Membrane-Coated Mesoporous Silica Nanoparticles for Targeted Delivery of Antibiotic Rifampicin against Gram-Negative Bacterial Infection In Vivo, Adv. Funct. Mater., 2021, 31, 2103442.
  15. X. Ding+*, H.M. Zhao+, Y.Z. Li, A. L. Lee, Z.S. Li, M.J. Fu, C.N. Li, Y. Y. Yang*, P.Y. Yuan*, Synthetic Peptide Hydrogels as 3D Scaffolds for Tissue Engineering, Adv. Drug Deliver. Rev., 2020, 160, 78-104.