邓文斌

职位

院长、教授、博士生导师

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dengwenbin

邓文斌,中山大学深圳药学院院长,加州大学戴维斯终身正教授、并任广东省干细胞与创新药物工程技术研究中心主任,长期从事干细胞与胶质细胞生物学及其在中枢神经再生中的基础与应用研究。发表相关SCI 80多篇,在神经干细胞和角质细胞研究领域取得了一系列创新性成果。

电子邮箱

dengwb5@mail.sysu.edu.cn

学科专业

药理学、生物化学、分子医学

个人经历

教育经历:

1. 1997/9-2001/7,美国新泽西州立罗格斯大学,药理毒理学,博士

2. 1991/9-1994/7,中国医学科学院北京协和医学院,药理学,硕士

3. 1985/9-1989/7,第二军医大学,药学,学士

科研与学术工作经历:

1. 2016/8-至今,中山大学,药学院(深圳),教授

2. 2014/7-2016/8,美国加州大学戴维斯分校,医学院生物化学和分子医学系,教授

3. 2010/7-2014/7,美国加州大学戴维斯分校,医学院生物化学和分子医学系,副教授

4. 2006/7-2010/7,美国加州大学戴维斯分校,医学院生物化学和分子医学系,助理教授

5. 2004/7-2006/7,哈佛大学,医学院,讲师

6. 2001/7-2004/7,哈佛大学医学院,博士后,合作导师:Frances E. Jensen

研究方向

神经胶质细胞及干细胞研究、新药研发

科研项目

1.国家自然科学基金面上项目,81772449,优化的iPS-Olig2阳性前体细胞来源的胶质细胞移植促进脊髓损伤修复的研究,2018/01-2021/1258万元,主持

2.广州市民生科技攻关计划,不同来源人诱导性多能干细胞向少突胶质前体细胞分化及促进髓鞘再生的临床前研究,2018.1-2.20.12.31100万,主持

3. 中山大学国家自然科学基金重大项目培育专项,基于新型人源性脑发育模型的星形胶质细胞发育异常的研究, 2018.01-2019.12.31 50万,主持

4. 中山大学国家重大科技项目前瞻培育专项,三种神经细胞亚型在脊髓损伤模型上的移植研究,2018.01-2019.12.31 50万,主持

 

代表论著

1.       Cheng XY, Li SY, Mao CJ, Wang MX, Chen J, Wang F, Wang GH, Deng WB, Li XK, Liu CF. Serum Response Factor Promotes Dopaminergic Neuron Survival via Activation of Beclin 1-Dependent Autophagy. Neuroscience. 2018 Feb 10;371:288-295.

2.       Tian Z, Zhao Q, Biswas S, Deng W. Methods of reactivation and reprogramming of neural stem cells for neural repair. Methods. 2018 Jan 15;133:3-20.

3.       Xiao J, Yang R, Biswas S, Zhu Y, Qin X, Zhang M, Zhai L, Luo Y, He X, Mao C, Deng W. Neural Stem Cell-Based Regenerative Approaches for the Treatment of Multiple Sclerosis. Mol Neurobiol. 2018 Apr;55(4):3152-3171.

4.       Jiang P, Deng W. Regenerating white matter using human iPSC-derived immature astroglia.Neurogenesis (Austin). 2016 Sep 8;3(1):e1224453.

5.       Chechneva OV, Deng W. Mitochondrial translocator protein (TSPO), astrocytes and neuroinflammation.Neural Regen Res. 2016 Jul;11(7):1056-7.

6.       Yechikov S, Copaciu R, Gluck JM, Deng W, Chiamvimonvat N, Chan JW, Lieu DK. Same-Single-Cell Analysis of Pacemaker-Specific Markers in Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Subtypes Classified by Electrophysiology. Stem Cells. 2016 Nov; 34(11):2670-2680.

7.       Jiang P, Chen C, Liu XB, Pleasure DE, Liu Y, Deng W. Human iPSC-Derived Immature Astroglia Promote Oligodendrogenesis by Increasing TIMP-1 Secretion. Cell Rep. 2016 May 10;15(6):1303-15.

8.       Tian Z, Guo F, Biswas S, Deng W. Rationale and Methodology of Reprogramming for Generation of Induced Pluripotent Stem Cells and Induced Neural Progenitor Cells. Int J Mol Sci. 2016 Apr 20;17(4). pii: E594.

9.       Daugherty DJ, Chechneva O, Mayrhofer F, Deng W. The hGFAP-driven conditional TSPO knockout is protective in a mouse model of multiple sclerosis. Sci Rep. 2016 Mar 1;6:22556.

10.   Zhai L, Wang L, Teng F, Zhou L, Zhang W, Xiao J, Liu Y, Deng W. Argonaute and Argonaute-Bound Small RNAs in Stem Cells. Int J Mol Sci. 2016 Feb 4;17(2):208.

11.   Liu XB, Shen Y, Pleasure DE, Deng W. The vulnerability of thalamocortical circuitry to hypoxic-ischemic injury in a mouse model of periventricular leukomalacia. BMC Neurosci. 2016 Jan 5;17:2.

12.   Chen C, Chan A, Wen H, Chung SH, Deng W, Jiang P. Stem and Progenitor Cell-Derived Astroglia Therapies for Neurological Diseases. Trends Mol Med. 2015 Nov;21(11):715-729.

13.   Liu Y, Deng W. Reverse engineering human neurodegenerative disease using pluripotent stem cell technology. Brain Res. 2016 May 1;1638(Pt A):30-41.

14.   Li S, Xue H, Wu J, Rao MS, Kim DH, Deng W, Liu Y. Human Induced Pluripotent Stem Cell NEUROG2 Dual Knockin Reporter Lines Generated by the CRISPR/Cas9 System. Stem Cells Dev. 2015 Dec 15;24(24):2925-42.

15.   Xiao J, Liu W, Chen Y, Deng W. Recombinant human PDCD5 (rhPDCD5) protein is protective in a mouse model of multiple sclerosis. J Neuroinflammation. 2015 Jun 12; 12:117.

16.   Chung SH, Biswas S, Selvaraj V, Liu XB, Sohn J, Jiang P, Chen C, Chmilewsky F, Marzban H, Horiuchi M, Pleasure DE, Deng W. The p38α mitogen-activated protein kinase is a key regulator of myelination and remyelination in the CNS. Cell Death Dis. 2015 May 7;6:e1748.

17.   Xiao J, Yang R, Biswas S, Qin X, Zhang M, Deng W. Mesenchymal stem cells and induced pluripotent stem cells as therapies for multiple sclerosis.Int J Mol Sci. 2015 Apr 24;16(5):9283-302.

18.   Chechneva OV, Deng W. Empowering sonic hedgehog to rescue brain cells after ischemic stroke. Neural Regen Res. 2015 Mar;10(3):360-2.

19.   Hammond E, Lang J, Maeda Y, Pleasure D, Angus-Hill M, Xu J, Horiuchi M, Deng W, Guo F. The Wnt effector transcription factor 7-like 2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt/β-catenin signaling. J Neurosci. 2015 Mar 25;35(12):5007-22.

20.   Xiao J, Yang R, Yang L, Fan X, Liu W, Deng W. Kirenol attenuates experimental autoimmune encephalomyelitis by inhibiting differentiation of Th1 and th17 cells and inducing apoptosis of effector T cells. Sci Rep. 2015 Mar 12;5:9022.

21.   Sohn J, Orosco L, Guo F, Chung SH, Bannerman P, Mills Ko E, Zarbalis K, Deng W, Pleasure D. The subventricular zone continues to generate corpus callosum and rostral migratory stream astroglia in normal adult mice. J Neurosci. 2015 Mar 4;35(9):3756-63.

22.   Qin X, Xu H, Gong W, Deng W. The Tumor Cytosol miRNAs, Fluid miRNAs, and Exosome miRNAs in Lung Cancer. Front Oncol. 2015 Jan 5; 4:357.

23.   Wu JJ, de Jager VC, Deng W, Leveau JH. Finished Genome Sequence of Collimonas arenae Cal35. Genome Announc. 2015 Jan 8;3(1). pii: e01408-14.

24.   Lo U, Selvaraj V, Plane JM, Chechneva OV, Otsu K, Deng W. p38α (MAPK14) critically regulates the immunological response and the production of specific cytokines and chemokines in astrocytes. Sci Rep. 2014 Dec 12;4:7405.

25.   Chechneva OV, Mayrhofer F, Daugherty DJ, Krishnamurty RG, Bannerman P, Pleasure DE, Deng W. A Smoothened receptor agonist is neuroprotective and promotes regeneration after ischemic brain injury. Cell Death Dis. 2014 Oct 23;5:e1481.

26.   Chen C, Jiang P, Xue H, Peterson SE, Tran HT, McCann AE, Parast MM, Li S, Pleasure DE, Laurent LC, Loring JF, Liu Y, Deng W. Role of astroglia in Down's syndrome revealed by patient-derived human-induced pluripotent stem cells. Nat Commun. 2014 Jul 18;5:4430.

27.   Morohaku K, Pelton SH, Daugherty DJ, Butler WR, Deng W, Selvaraj V. Translocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis. Endocrinology. 2014 Jan;155(1):89-97.

28.   Li Y, Xiao K, Zhu W, Deng W, Lam KS. Stimuli-responsive cross-linked micelles for on-demand drug delivery against cancers. Adv Drug Deliv Rev. 2014 Feb;66:58-73.

29.   Jiang P, Chen C, Wang R, Chechneva OV, Chung SH, Rao MS, Pleasure DE, Liu Y, Zhang Q, Deng W. hESC-derived Olig2+ progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury. Nat Commun. 2013;4:2196.

30.   Daugherty DJ, Selvaraj V, Chechneva OV, Liu XB, Pleasure DE, Deng W. A TSPO ligand is protective in a mouse model of multiple sclerosis.EMBO Mol Med. 2013 Jun;5(6):891-903.

31.   Chung SH, Guo F, Jiang P, Pleasure DE, Deng W. Olig2/Plp-positive progenitor cells give rise to Bergmann glia in the cerebellum.Cell Death Dis. 2013 Mar 14;4:e546.