谢智勇

职位

教授、博士生导师

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谢智勇博士,教授,博士生导师,药学院院长助理。湖南中医药大学药学学士,沈阳药科大学药学博士(药物代谢与药代动力学方向),加拿大University of Toronto访问学者(2011-2012)。主要研究方向为代谢组分析新技术新方法、肠道微生物组学、药物代谢与药代动力学。近年主要专注于基于肠道微生态学结合代谢组学的中药药效物质基础及其作用机制研究,探索慢性非传染炎症性疾病(肥胖、糖尿病、炎症性肠病等)的代谢组学基础及其“肠道菌群-宿主代谢”相互调控分子机制,开展基于肠道菌群为靶标的保健食品、创新中药的研制及其防治疾病的机制研究。已主持国家自然科学基金、国家科技支撑计划项目子课题、“重大新药创制”国家科技重大专项子课题等课题10余项。已在J Chromatogr A, Anal Bioanal Chem, RSC Adv, Bioanalysis, J Pharm Biomed Anal, J Chromatogr B, J Ethnopharmacol, Fitoterapia, Phytochem Anal, J Sep Sci 等国内外专业期刊共发表论文100余篇,其中SCI收录70余篇,参编《药物分析学》等专著6部。国家自然科学基金、广东省自然科学基金评审专家;广东省科技厅、广州市科信局专家库专家;广东省食品药品监督管理局保健食品审评专家;广东省食品药品监督管理局保健食品审评专家;中国芦荟专业委员会专家,国家新食品资源健康产业技术创新战略联盟专家委员会委员,广东省保健食品产业技术创新联盟专家委员会委员,广东药学会制药工程专业委员会常务委员,the International Society for the Study of Xenobiotics (ISSX)和American Association of Pharmaceutical Scientists (AAPS) 会员;Asian Journal of Beauty & Cosmetology和 Journal of Investigative Cosmetology and Dermatology 两国际期刊的编委,J Chromatogr A, Bioanalysis, J Pharm Biomed Anal, Anal Meth, J Chromatogr B, J Sep Sci等国际期刊的特邀审稿人。

电子邮箱

xiezhy@mail.sysu.edu.cn

个人经历

教育经历
2011.01-2012.01   加拿大University of Toronto药学院 访问学者
2000.09-2005.06   沈阳药科大学,硕博连读,药学分析学博士
1993.09-1997.06   湖南中医药大学,药学学士

工作经历
2016.06-今         中山大学药学院         博士生导师
2015.01-今         中山大学药学院         教授
2012.06-今         中山大学药学院         院长助理
2009.04-2010.04    借调到中国科技部中国生物技术发展中心
2008.12-2015.01    中山大学药学院      副教授
2007.11-2008.11    借调到广东省科学技术厅
2005.07-2008.12    中山大学药学院        讲  师
 

研究方向

药物分析学、药物代谢与药代动力学、代谢组学、肠道微生物组学

科研项目

1. 国家自然科学基金项目:基于肠道微生态学结合代谢组学的黄连解毒汤改善2型糖尿病胰岛素抵抗的药效物质基础及其作用机制研究;

2. 国家自然科学基金项目:基于整体观(代谢组学结合肠道微生态学)黄连解毒汤“减毒增效”配伍机制的研究;

3. 国家自然科学基金项目:黄连配伍吴茱萸复方活性成分的药代动力学及其配伍机制研究

4. 广东省自然科学基金:基于肠道微生态学结合代谢组学的黄连解毒汤改善2型糖尿病胰岛素抵抗的作用机制研;

5. 广东省科技计划项目:芦荟蒽醌与芦荟多糖新检测方法的开发及芦荟产品认证标准体系的建立

6. 国家科技支撑计划项目子课题:芦荟中蒽醌等功能性提取物的创制与应用;

7. “重大新药创制”国家科技重大专项子课题:癌症疼痛治疗药-苯胺洛芬注射液的临床前研究;

8. 广东省教育部产学研结合项目:无患子皂苷分离纯化、结构改性及其产业化应用研究;

9. 广州市科技计划项目:芦荟的药效物质基础及其用于鼻咽癌放疗辅助治疗的作用研究;

10. 中山大学青年教师培育项目:基于血脑屏障P-糖蛋白功能及其信号通路的冰片“醒脑开窍”分子机制研究

代表论著

参编专著:

1.全国高等医药院校规划教材《药物分析(案例版)》(第1版),中国科技出版社,2010.08 编委(3万字)。

2.全国高等医药院校规划教材《药物分析(案例版)》(第2版),中国科技出版社,2017.03 副主编(3万字)。

3.中国芦荟产业认证战略研究,中国劳动社会保障出版社,2013.06,编委(2.5万字)。

4.“十二五”普通高等教育本科国家级规划教材,全国高等学校药学类规划教材《药物分析学》(第2版),高等教育出版社,2014.02,编委(3.6万字)。

5. 中国芦荟产业发展报告(2014),中国科学技术出版社,2015.07,编委(4万字)

 

发表论文(近三年)
1.    Waner Hou#, Danmin Zhong#, Peiting Zhang, Yemeng Li, Manna Lin, Guanghui Liu, Meicun Yao, Qiongfeng Liao*, Zhiyong Xie*. A Strategy for the Targeted Metabolomics Analysis of 11 Gut Microbiota-host Co-metabolites in Rat Serum, Urine and Feces by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry. Journal of Chromatography A, 2016, 1429: 207-217.
2.    Jiahui Chen#, Waner Hou#, Bo Han, Guanghui Liu, Jin Gong, Yemeng Li, Danmin Zhong, Qiongfeng Liao*, Zhiyong Xie*. Target-based Metabolomics for the Quantitative Measurement of 37 Pathway Metabolites in Rat Brain and Serum using Hydrophilic Interaction Ultra-High-Performance Liquid Chromatography-tandem Mass Spectrometry. Analytical and Bioanalytical Chemistry. 2016, 408(10): 2527-2542. 
3.    Yemeng Li#, Qiongfeng Liao#, Manna Lin, Danmin Zhong, Lin Wei, Bo Han, Hui Miao, Meicun Yao, Zhiyong Xie*. An integrated metabonomics and microbiology analysis of host-microbiota metabolic interactions in rats with Coptis chinensis-induced diarrhea. RSC Advances, 2015, 5, 79329-79341. doi: 10.1039/c5ra16338b.
4.    anna Lin#, Zhiyong Xie#, Yuting Zhou, Yemeng Li, Jian Ren, Xuanxian Peng, Meicun Yao, Zhongzhou Yang, Qiongfeng Liao*. Dynamic Metabonomic and Microbiological Response of Rats to Lincomycin Exposure: An Integrated Microbiology and Metabonomics Analysis. RSC Advances, 2015, 5, 65415-65426. doi: 10.1039/C5RA10626E.
5.    Jing Gong, Hui Miao, Xiuman Sun, Waner Hou, Jiahui Chen, Zhiyong Xie*, Qiongfeng Liao*. Simultaneous qualitative and quantitative determination of phenylethanoid glycosides and flavanoid compounds in Callicarpa kwangtungensis Chun by HPLC-ESI-IT-TOF-MS/MS coupled with HPLC-DAD. Analytical Method, 2016, 8(33), 6323.
6.    Lin Wei, Manna Lin, Bo Han, Xuejiao Deng, Waner Hou, Qiongfeng Liao*, Zhiyong Xie*. The Comparison of Cinnamomi Cortex and Cinnamomum burmannii Blume Using 1H NMR and GC-MS Combined with Multivariate Data Analysis. Food Analytical Methods 2016, 9, 2419-2428, doi:10.1007/s12161-016-0418-5.
7.    Jiasheng Zhong, Jinzhi Wan*, Wenjng Ding, Xiaofang Wu, Zhiyong Xie*. Multi-responses extraction optimization combined with high-performance liquid chromatography–diode array detection–electrospray ionization-tandem mass spectrometry and chemometrics techniques for the fingerprint analysis of Aloe barbadensis Miller. Journal of Pharmaceutical and Biomedical Analysis. 2015, 107: 131-140.
8.    Jiasheng Zhong, Jinzhi Wan*, Xiaoqi Jiang, Wenjing Ding, Xiaofang Wu, Zhiyong Xie*. Optimization of the Preparation of a Minor Bioactive Chromone in Aloe barbadensis Miller using Response Surface Methodology and its Isolation by Reversed-phase Flash Chromatography. Separation Science and Technology, 2015, 50: 774-751. 
9.    Hao Cai, Zhiyong Xie*, Guanghui Liu, Xiuman Sun, Guangtian Peng, Baoqin Lin, Qiongfeng Liao*. Isolation, Identification and Activities of Natural Antioxidants from Callicarpa kwangtungensis Chun. PloS ONE, 9(3): e93000. 
10.    Yuting Zhou#, Qiongfeng Liao#, Manna Lin, Xuejiao Deng, Peiting Zhang, Meicun Yao,Lei Zhang, Zhiyong Xie*.Combination of 1H NMR- and GC-MS-Based Metabonomics to Study on the Toxicity of Coptidis Rhizome in Rats. PLoS One. 2014, 9(2):e88281. doi: 10.1371/journal.pone.0088281. 
11.    Wei He, Guanghui Liu, Hao Cai, Xiuman Sun, Waner Hou, Peiting Zhang, Zhiyong Xie*, Qiongfeng Liao*. Integrated pharmacokinetics of five protoberberine-type alkaloids in normal and insomnic rats after single and multiple oral administration of jiao-Tai-wan. Journal of Ethnopharmacology. 2014, 154(3): 635-644. 
12.    Peiting Zhang, Yemeng Li, Guanghui Liu, Xiuman Sun, Yuting Zhou, Xuejiao Deng, Qiongfeng Liao, Zhiyong Xie*. Simultaneous determination of atropine, scopolamine and anisodamine from Hyoscyamus niger L. in rat plasma by high performance liquid chromatography with tandem mass spectrometry and its application to pharmacokinetics study. Journal of Separation Science, 2014, 37(19): 2664-2674.
13.    Jiasheng Zhong, Jinzhi Wan*, Wenjing Ding, Xiaofang Wu,Zhiyong Xie*. One-step Separation and Purification of Two Chromones and One Pyrone from Aloe barbadensis Miller: a Comparison Between Reversed-phase Flash Chromatography and High-speed Counter Current Chromatography. Phytochemical Analysis. 2014, 25, 282-288. 
14.    Waner Hou, Guanghui Liu, Xiuman Sun, Zhiyong Xie,* Rongbiao Pi, Wei He, Manna Lin and Qiongfeng Liao*. Determination of newly synthesized lipoic acid–fasudil dimer in rat plasma by LC-MS/MS and its application to pharmacokinetics study. Analytical Methods, 2014, 6(21), 8675-8681.
15.    Jiasheng Zhong, Jinzhi Wan*, Yupeng Liu, Wenjing Ding, Xiaofang Wu, Zhiyong Xie*, Simultaneous HPLC quantification of seven chromones in Aloe barbadensis Miller using a single reference standard. Analytical Methods, 2014, 6(12) 4388-4395. doi: 10.1039/C4AY00031E. 
16.    Guanghui Liu, Wei He, Hao Cai, Xiuman Sun, Waner Hou, Manna Lin, Zhiyong Xie*, Qiongfeng Liao*. The simultaneous determination of berberine, palmatine, coptisine, epiberberine and jatrorrhizine in rat plasma by LC-MS/MS and its pharmacokinetic comparison after the oral administration of Rhizoma Coptidis and Jiao-Tai-Wan extract. Analytical Methods. 2014, 6(9), 2998-3008. doi: 10.1039/c3ay42000k. 
17.    Xiuman Sun,Peiting Zhang, Rongbiao Pi, Yuting Zhou, Xuejiao Deng, Zhiyong Xie*, Qiongfeng Liao*. Determination of Tacrine-6-ferulic acid in rat plasma by LC-MS/MS and its application to pharmacokinetics study. Biomedical Chromatography. 2014. 28(10): 1352-1359. 
18.    Xuejiao Deng, Qiongfeng Liao, Xinjun Xu, Meicun Yao ,Yuting Zhou, Manna Lin, Peiting Zhang, Zhiyong Xie*.Analysis of Essential Oils from Cassia Bark and Cassia Twig Samples by GC-MS Combined with Multivariate Data Analysis. Food Analytical Methods. 2014, 7: 1840-1847. doi: 10.1007/s12161-014-9821-y
19.    Chun Wu#, Qiongfeng Liao#, Meicun Yao, Xinjun Xu, Yuting Zhou, Xueying Hou, Zhiyong Xie*. Effect of natural borneol on the pharmacokinetics and distribution of nimodipine in mice. European Journal of Drug Metabolism and Pharmacokinetics. 2014, 39(1):17-24. doi: 10.1007/s13318-013-0135-z. Epub 2013 May 15.
20.    Peiting Zhang#, Biyan Pan#, Qiongfeng Liao, Meicun Yao, XinJun Xu, Jinzhi Wan, Dan Liu, Zhiyong Xie*.Separation of Five Quinolone Alkaloids from Fruits of Evodia rutaecarpa by High-speed Counter-current Chromatography. Chinese Herbal Medicines. 2014, 6(1): 47-52.
21.    Xiuman Sun, Qiongfeng Liao, Yuting Zhou, Xuejiao Deng, Zhiyong Xie*. Simultaneous determination of borneol and its metabolite in rat plasma by GC-MS and its application to pharmacokinetics study. Journal of Pharmaceutical Analysis. 2014, 4(5): 345-350.