覃静

职位

副教授,硕士生导师

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覃静

中山大学“百人计划”引进人才,副教授。2013年获香港大学李嘉诚医学院生物信息学博士学位。之后曾任香港大学李嘉诚医学院博士后及香港中文大学生命科学学院研究助理教授。从事生物信息学分析方法的研究及其在医药学中的应用。曾开发多个针对基因调控机制研究的分析工具与方法,并应用于探索干细胞分化、颅骨发育、免疫应答等过程与癌症、心脏病、肾病等疾病中基因调控机制的问题。这些方法与研究成果已发表于Nucleic Acids Research, Nature Communications, eLife, Bioinformatics, BMC Genomics, Journal of Machine Learning Research等国际一流杂志。

电子邮箱

qinj29@mail.sysu.edu.cn

学科专业

生物信息学、系统生物学

个人经历

2002-2006   浙江大学竺可桢学院 生物科学,获学士学位

2006-2009   香港中文大学生物系 生物专业,获硕士学位

2010-2013   香港大学李嘉诚医学院 生物信息,获博士学位

2013-2015   香港大学李嘉诚医学院,博士后

2015-2018   香港中文大学生命科学学院,研究助理教授

2018年至今                中山大学,药学院(深圳),副教授,硕导

研究方向

疾病基因调控机制研究寻找新的药物靶点。

药理研究与病理匹配提供个性化医疗策略。

eRNA变异与癌症发生的关系研究及CRISPR技术逆转细胞病变的探索。

细胞重编程关键因子的预测

从核酸结合蛋白的功能复杂性研究DNARNA和蛋白相互作用的异常与疾病的关系。

科研项目

012017年度国家自然科学基金青年基金项目,项目编号:41606143,角色:主持,状态:进行中

022017 AstraZeneca Oncology Research Program,角色:主持,状态:进行中

032013年度国家自然科学基金重大研究计划培育项目,项目编号:91229105,角色:参与,状态:已结题

代表论著

近年发表的学术论文

1.      Leung, R.W.T., Jiang, X., Chu, K.H., Qin, J.* (2019) ENPD - a database of eukaryotic nucleic acid binding proteins: linking gene regulations to proteins. Nucleic Acids Research 47, D322-D329. [*corresponding author]

2.      Ma, K.Y., Qin, J., Lin, C.-W., Chan, T.-Y., Ng, P.K.L., Chu, K.H. and Tsang, L.M. (2019) Phylogenomic analyses of brachyuran crabs support early divergence of primary freshwater crabs. Molecular Phylogenetics and Evolution, accepted.

3.      Qin, J.*, Hu, Y., Ma, K.Y., Jiang, X., Ho, C.H., Tsang, L.M., Yi, L., Leung, R.W.T. and Chu, K.H.* (2017) CrusTF: a comprehensive resource of transcriptomes for evolutionary and functional studies of crustacean transcription factors. BMC Genomics 18, 908. [*co-corresponding authors]

4.      Hu, Y., Li, C., Meng, K., Qin, J., and Yang, X. (2017). Group sparse optimization via ℓp,q regularization. Journal of Machine Learning Research, 18, 1-53. (Authors in alphabetical order)

5.      Yan, B., Guan, D., Wang, C., Wang, J., He, B., Qin, J., Boheler, K.R., Lu, A., Zhang, G., and Zhu, H. (2017). An integrative method to decode regulatory logics in gene transcription. Nature Communications 8, 1044.

6.      Xiao, Z.J., Liu, J., Wang, S.Q., Zhu, Y., Gao, X.Y., Tin, V.P., Qin, J., Wang, J.W., and Wong, M.P. (2017). NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2/ALDH axis in lung adenocarcinoma. eLife 6, e26733.

7.      Tang, J., Shen, Y., Chen, G., Wan, Q., Wang, K., Zhang, J., Qin, J., Liu, G., Zuo, S., Tao, B., Yu, Y., Wang, J., Lazarus, M., and Yu. Y. (2017). Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction. Nature Communications 8, 14656.

8.      Qu, L., Lu, Y., Ying, M., Li, B., Weng, C., Xie, Z., Liang, L., Lin, C., Yang, X., Feng, S., Wang, Y., Shen, X., Zhou, Q., Chen, Y., Chen, Z., Wu, J., Lin, W., Shen, Y., Qin, J., Xu, H., Xu, F., Wang, J., Chen, J., Jiang, H. and Huang, H. (2017) Tacrolimus dose requirement based on the CYP3A5 genotype in renal transplant patients. Oncotarget 8, 81285-81294.

9.      Qin, J., Yan, B., Hu, Y., Wang, P. and Wang, J. (2016) Applications of integrative OMICs approaches to gene regulation studies. Quantitative Biology 4, 283-301.

10.  Bildsoe, H., Fan, X., Wilkie, E.E., Ashoti, A., Jones, V.J., Power, M., Qin, J., Wang, J., Tam, P.P.L. and Loebel, D.A.F. (2016) Transcriptional targets of TWIST1 in the cranial mesoderm regulate cell-matrix interactions and mesenchyme maintenance. Developmental Biology 418, 189-203.

11.  Jiang, H., Liang, L., Qin, J., Lu, Y., Li, B., Wang, Y., Lin, C., Zhou, Q., Feng, S., Yip, S.H. et al. (2016) Functional networks of aging markers in the glomeruli of IgA nephropathy: a new therapeutic opportunity. Oncotarget 7, 33616-33626.

12.  Kwok, C.T., Leung, M.H., Qin, J., Qin, Y., Wang, J., Lee, Y.L., and Yao, K.M. (2016). The Forkhead box transcription factor FOXM1 is required for the maintenance of cell proliferation and protection against oxidative stress in human embryonic stem cells. Stem Cell Research 16, 651-661.

13.  Fan, X., Loebel, D.A.F., Bildsoe, H., Wilkie, E.E., Qin, J., Wang, J. and Tam, P.P.L. (2016) Tissue interactions, cell signaling and transcriptional control in the cranial mesoderm during craniofacial development. AIMS Genetics 3, 74-98.

14.  Wang, P.#, Qin, J.#, Qin, Y., Zhu, Y., Wang, L.Y., Li, M. J., Zhang, M. Q. and Wang, J. (2015). ChIP-Array 2: integrating multiple OMICs data to construct gene regulatory networks. Nucleic Acids Research 43, W264-269. [# equal contribution]

15.  Qin, Y., Yalamanchili, H.K., Qin, J., Yan, B. and Wang, J. (2015) The current status and challenges in computational analysis of genomic big data. Big Data Research 2, 12-18.

16.  Cheng, C.K., Cheung, M.K., Nong, W., Law, P.T., Qin, J., Ling, J.M., Kam, K.M., Cheung, W.M. and Kwan, H.S. (2015) Next generation genome sequencing reveals phylogenetic clades with different level of virulence among Salmonella Typhimurium clinical human isolates in Hong Kong. BMC Genomics 16, 688.

17.  Yu, Y., Qin, J., Chen, D., Wang, H., Wang, J., and Yu, Y. (2015). Chronic cardiovascular disease-associated gene network analysis in human umbilical vein endothelial cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Cardiovascular Toxicology 15, 157-171.

18.  Qin, J.#, Hu, Y. #, Xu, F., Yalamanchili, H.K., and Wang, J. (2014). Inferring gene regulatory networks by integrating ChIP-seq/chip and transcriptome data via LASSO-type regularization methods. Methods 67, 294-303. [# equal contribution]

19.  Wang, Q., He, Y., Shen, Y., Zhang, Q., Chen, D., Zuo, C., Qin, J., Wang, H., Wang, J., and Yu, Y. (2014). Vitamin D inhibits COX-2 expression and inflammatory response by targeting thioesterase superfamily member 4. Journal of Biological Chemistry 289, 11681-11694.

20.  Guan, D., Shao, J., Zhao, Z., Wang, P., Qin, J., Deng, Y., Boheler, K.R., Wang, J., and Yan, B. (2014). PTHGRN: unraveling post-translational hierarchical gene regulatory networks using PPI, ChIP-seq and gene expression data. Nucleic Acids Research 42, W130-136.

21.  Zhang, L., Zhu, C., Guo, Y., Wei, F., Lu, J., Qin, J., Banerjee, S., Wang, J., Shang, H., Verma, S.C., Yuan, Z., Robertson E.S., and Cai, Q. (2014). Inhibition of KAP1 enhances hypoxia-induced Kaposi's sarcoma-associated herpesvirus reactivation through RBP-Jkappa. Journal of Virology 88, 6873-6884.

22.  Yalamanchili, H.K., Yan, B., Li, M.J., Qin, J., Zhao, Z., Chin, F.Y., and Wang, J. (2014). DDGni: dynamic delay gene-network inference from high-temporal data using gapped local alignment. Bioinformatics 30, 377-383.

23.  Qin, J., Li, M.J., Wang, P., Wong, N.S., Wong, M.P., Xia, Z., Tsao, G.S., Zhang, M.Q., and Wang, J. (2013). ProteoMirExpress: inferring microRNA and protein-centered regulatory networks from high-throughput proteomic and mRNA expression data. Molecular & Cellular Proteomics 12, 3379-3387.

24.  Qin, J., Li, M.J., Wang, P., Zhang, M.Q., and Wang, J. (2011). ChIP-Array: combinatory analysis of ChIP-seq/chip and microarray gene expression data to discover direct/indirect targets of a transcription factor. Nucleic Acids Research 39, W430-436. [Recommended by F1000Prime]

25.  Wang, L.Y., Wang, P., Li, M.J., Qin, J., Wang, X., Zhang, M.Q., and Wang, J. (2011). EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans. Epigenetics 6, 1505-1512.