Publications

Representative publications

  1. Zhao XY, Zhao BC, Li HL, Liu Y, Wang B, Li AQ, Zeng TS, Hui HX, Sun J, Cikes D, Gheldof N, Hager J, Mi JX, Laybutt DR, Deng YY, Shi YC, Neely GG, Wang QP. MTCH2 Suppresses Thermogenesis by Regulating Autophagy in Adipose Tissue. Adv Sci. 2025 Mar 7:e2416598. doi: 10.1002/advs.202416598.
  2. Wang, B.#, Wan, A.H.#, Xu, Y.#, Zhang, R.X., Zhao, B.C., Zhao, X.Y., Shi, Y.C., Zhang, X., Xue, Y., Luo, Y., et al. (2023). Identification of indocyanine green as a STT3B inhibitor against mushroom alpha-amanitin cytotoxicity. Nat Commun 14, 2241. https://doi.org/10.1038/s41467-023-37714-3.
  3. Wang Bei#, Xu, Yu#, Wan, A.H#,Guohui Wan*, Qiao-Ping Wang*. Integrating Genome-Wide CRISPR Screens and In Silico Drug Profiling for Targeted Antidote Development.  Nat Protoc 2024. https://doi.org/10.1038/s41596-024-00995-z
  4. Xin-Yuan Zhao#, Ying Liu#, Xuan Zhang#, Ben-Chi Zhao, George Burley, Zhi-Can Yang, Yi Luo, An-Qi Li, Ruo-Xin Zhang, Zhi-Ying Liu, Yan-Chuan Shi, Qiao-Ping Wang，The combined effect of metformin and mirabegron on diet-induced obesity. MedComm. 2023; 4:e207. https://doi.org/10.1002/mco2.207.
  5. Wang QP#, Lin YQ, Lai ML, Su Z, Oyston LJ, Clark T, Park SJ, Khuong TM, Lau MT, Shenton V, Shi YC, James DE, Ja WW, Herzog H, Simpson SJ, Neely GG#.PGC1α Controls Sucrose Taste Sensitization in Drosophila. Cell Rep. 2020 Apr 7;31(1):107480. doi: 10.1016/j.celrep.2020.03.044. Corresponding author 
  6. Wang QP, Lin YQ, Zhang L, Wilson YA, Oyston LJ, Cotterell J, Qi Y, Khuong TM, Bakhshi N, Planchenault Y, Browman DT, Lau MT, Cole TA, Wong AC, Simpson SJ, Cole AR, Penninger JM, Herzog H, Neely GG. Sucralose Promotes Food Intake through NPY and a Neuronal Fasting Response. Cell Metab. 2016 Jul 12;24(1):75-90 (selected as Nature research highlight and Sci Signaling editorial，BBC news reported,  IF:22.4）
  7. Wang QP, Simpson SJ, Herzog H, Neely GG. Chronic Sucralose or L-Glucose Ingestion Does Not Suppress Food Intake. Cell Metab. 2017;26(2):279-280（IF:22.4）
  8. Valsesia A*, Wang QP*, Gheldof N, Carayol J, Ruffieux H, Clark T, Shenton V, Oyston LJ, Lefebvre G, Metairon S, Chabert C, Walter O, Mironova P, Lau P, Descombes P, Viguerie N, Langin D, Harper ME, Astrup A, Saris WH, Dent R, Neely GG, Hager J.  Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism. Nat Commun. 2019 Feb 1;10(1):540. 10.1038/s41467-019-08492-8 (*co-first author, IF:11.9)
  9. Orthofer M#, Valsesia A#, Mägi R#, Wang QP, Kaczanowska J, Kozieradzki I, Leopoldi A, Cikes D, Zopf LM, Tretiakov EO, Demetz E, Hilbe R, Boehm A, Ticevic M, Nõukas M, Jais A, Spirk K, Clark T, Amann S, Lepamets M, Neumayr C, Arnold C, Dou Z, Kuhn V, Novatchkova M, Cronin SJF, Tietge UJF, Müller S, Pospisilik JA, Nagy V, Hui CC, Lazovic J, Esterbauer H, Hagelkruys A, Tancevski I, Kiefer FW, Harkany T, Haubensak W, Neely GG, Metspalu A, Hager J*, Gheldof N*, Penninger JM*.. Identification of ALK in Thinness. Cell 181, 1–17. DOI：10.1016/j.cell.2020.04.034
  10. Khuong TM, Wang QP, Manion J, Oyston LJ, Lau MT, Towler H, Lin YQ, Neely GG. Nerve injury drives a heightened state of vigilance and neuropathic sensitization in Drosophila. Sci Adv. 2019 Jul; 5(7):eaaw4099.(IF:11.5)
  11. Wong AC, Wang QP, Morimoto J, Senior AM, Lihoreau M, Neely GG, Simpson SJ, Ponton F. Gut microbiota modifies olfactory-guided microbial attraction in Drosophila. Curr Biol. 2017 ;27(15):2397-2404（IF:9.2）
  12. Wang QP, Lai DH, Zhu XQ, Chen XG, Lun ZR. Human angiostrongyliasis. Lancet Infect Dis 2008; 10: 621-630. (IF:27.5）

 

Full list of publications

****2025****

  1. Zhao XY, Zhao BC, Li HL, Liu Y, Wang B, Li AQ, Zeng TS, Hui HX, Sun J, Cikes D, Gheldof N, Hager J, Mi JX, Laybutt DR, Deng YY, Shi YC, Neely GG, Wang QP. MTCH2 Suppresses Thermogenesis by Regulating Autophagy in Adipose Tissue. Adv Sci. 2025 Mar 7:e2416598. doi: 10.1002/advs.202416598.
  2. Wang QP, Li AQ, Wang B, Zhao XY, Li SS, Herzog H, Neely GG. Sucralose uses reward pathways to promote acute caloric intake. Neuropeptides. 2025 Mar; 110:102502. doi: 10.1016/j.npep.2025.102502
  3. Li AQ, Li SS, Li HL, Zhong LL, Tian GB, Zhao XY, Wang QP. A rapid and reproducible method for generating germ-free Drosophila melanogaster. Biophys Rep. 2024 Dec 31;10(6):364-368. doi: 10.52601/bpr.2024.240025.

****2024****

  1. Zhao Xinyuan, Wang Jiqiu, Neely G.Gregory., Shi Yanchuang, Wang Qiaoping. (2024). Natural compounds as obesity pharmacotherapies.  Phytother Res 38, 797-838. https://doi.org/10.1002/ptr.8083.
  2. Li, S.S., Li, A.Q., Liu, Z.Y., Zhao, X.Y., Wang, G.R., Deng, Y., and Wang, Q.P. (2024). Glutamine enhances sucrose taste through a gut microbiota-gut-brain axis in Drosophila. Life Sci 339, 122415. https://doi.org/10.1016/j.lfs.2024.122415.
  3. Wang Bei#, Xu, Yu#, Wan, A.H#,Guohui Wan*, Qiao-Ping Wang*. Integrating Genome-Wide CRISPR Screens and In Silico Drug Profiling for Targeted Antidote Development.  Nature Protocols 2024. https://doi.org/10.1038/s41596-024-00995-z

 

****2023****

  1. Lai ML#, Li AQ#, Senior AM, Neely GG, Simpson SJ, Wang QP. Nutritional geometry framework of sleep. Life Sci. 2023;316:121381. doi:10.1016/j.lfs.2023.121381
  2. An-Qi Li, Sha-Sha Li, Ruo-Xin Zhang, Xin-Yuan Zhao, Zhi-Ying Liu, Yun Hu, Bei Wang, G Gregory Neely, Stephen J. Simpson, Qiao-Ping Wang(2023). Nutritional geometry framework of sucrose taste in Drosophila. Journal of Genetics and Genomics. DOI: https://doi.org/10.1016/j.jgg.2023.02.001.
  3. Xin-Yuan Zhao#, Ying Liu#, Xuan Zhang#, Ben-Chi Zhao, George Burley, Zhi-Can Yang, Yi Luo, An-Qi Li, Ruo-Xin Zhang, Zhi-Ying Liu, Yan-Chuan Shi, Qiao-Ping Wang，The combined effect of metformin and mirabegron on diet-induced obesity. MedComm. 2023; 4:e207. https://doi.org/10.1002/mco2.207.
  4. Wang, B.#, Wan, A.H.#, Xu, Y.#, Zhang, R.X., Zhao, B.C., Zhao, X.Y., Shi, Y.C., Zhang, X., Xue, Y., Luo, Y., et al. (2023). Identification of indocyanine green as a STT3B inhibitor against mushroom alpha-amanitin cytotoxicity. Nat Commun 14, 2241. https://doi.org/10.1038/s41467-023-37714-3.

 

****2022****

  1. YANG Zhican#, ZHAO Xinyuan#, LIU Ying, ZHAO Benchi, LUO Yi, KANG Jiansheng, WANG Qiaoping. Treating obesity using the combination of metformin and epigallocatechin-3-gallate. Journal of Holistic Integrative Pharmacy, 2022, 3(1): 57-67.
  2. Yun Hu#, Zhi-Ying Liu#, Sha-Sha Li, An-Qi Li, Qiao-Ping Wang (2022). AMPK controls sucrose taste sensitization in Drosophila. Journal of Genetics and Genomics.DOI: ‍https://doi.org/10.1016/j.jgg.2022.04.015
  3. Zhang RX, Li SS, Li AQ, Liu ZY, Neely GG, Wang QP. dSec16 Acting in Insulin-like Peptide Producing Cells Controls Energy Homeostasis in Drosophila. Life (Basel). 2022;13(1):81. Published 2022 Dec 27. doi:10.3390/life13010081
  4. Wang B#, Chen JZ#, Luo XQ, Wan GH, Tang YL, Wang QP. The application of genome-wide CRISPR-Cas9 screens to dissect the molecular mechanisms of toxins. Comput Struct Biotechnol J. 2022 Sep 13;20:5076-5084. doi: 10.1016/j.csbj.2022.09.012. PMID: 36187925; PMCID: PMC9489804.

 

****2021****

  1. Chenxu Yan, Tianshu Zeng, Kailun Lee, Max Nobis, Kim Loh, Luoning Gou, Zefeng Xia, Zhongmin Gao, Mohammed Bensellam, Will Hughes, Jackie Lau, Lei Zhang, Chi Kin Ip, Ronaldo Enriquez, Hanyu Gao, Qiao-Ping Wang, Qi Wu, Jody J. Haigh, D. Ross Laybutt, Paul Timpson, Herbert Herzog & Yan-Chuan Shi. Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity. Nat Commun  2021;12, 2622. https://doi.org/10.1038/s41467-021-22925-3

 

****2020****

  1. Khoury S, Wang QP, Parisien M, Gris P, Bortsov AV, Linnstaedt SD, McLean SA, Tungate AS, Sofer T, Lee J, Louie T, Redline S, Kaunisto MA, Kalso EA, Munter HM, Nackley AG, Slade GD, Smith SB, Zaykin DV, Fillingim RB, Ohrbach R, Greenspan JD, Maixner W, Neely GG, Diatchenko L. Multi-ethnic GWAS and meta-analysis of sleep quality identify MPP6 as a novel gene that functions in sleep center neurons. Sleep. 2020 Oct 9: zsaa21 doi: 10.1093/sleep/zsaa211. IF:4.805
  2. Orthofer M#, Valsesia A#, Mägi R#, Wang QP, Kaczanowska J, Kozieradzki I, Leopoldi A, Cikes D, Zopf LM, Tretiakov EO, Demetz E, Hilbe R, Boehm A, Ticevic M, Nõukas M, Jais A, Spirk K, Clark T, Amann S, Lepamets M, Neumayr C, Arnold C, Dou Z, Kuhn V, Novatchkova M, Cronin SJF, Tietge UJF, Müller S, Pospisilik JA, Nagy V, Hui CC, Lazovic J, Esterbauer H, Hagelkruys A, Tancevski I, Kiefer FW, Harkany T, Haubensak W, Neely GG, Metspalu A, Hager J*, Gheldof N*, Penninger JM*.. Identification of ALK in Thinness. Cell 181, 1–17. DOI：10.1016/j.cell.2020.04.034
  3. Wang QP#, Lin YQ, Lai ML, Su Z, Oyston LJ, Clark T, Park SJ, Khuong TM, Lau MT, Shenton V, Shi YC, James DE, Ja WW, Herzog H, Simpson SJ, Neely GG#.PGC1α Controls Sucrose Taste Sensitization in Drosophila. Cell Rep. 2020 Apr 7;31(1):107480. doi: 10.1016/j.celrep.2020.03.044. #co-corresponding author
  4. Yuan Y, Xu P, Jiang Q, Cai X, Wang T, Peng W, Sun J, Zhu C, Zhang C, Yue D, He Z, Yang J, Zeng Y, Du M, Zhang F, Ibrahimi L, Schaul S, Jiang Y, Wang J, Sun J, Wang Q, Liu L, Wang S, Wang L, Zhu X, Gao P, Xi Q, Yin C, Li F, Xu G, Zhang Y, Shu G. Exercise-induced α-ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation. EMBO J. 2020 Apr 1;39(7):e103304. doi: 10.15252/embj.2019103304. Epub 2020 Feb 27.
     

****2019****

  1. Su Z, Burchfield JG, Yang P, Humphrey SJ, Yang G, Francis D, Yasmin S, Shin SY, Norris DM, Kearney AL, Astore MA, Scavuzzo J, Fisher-Wellman KH, Wang QP, Parker BL, Neely GG, Vafaee F, Chiu J, Yeo R, Hogg PJ, Fazakerley DJ, Nguyen LK, Kuyucak S, James DE.Global redox proteome and phosphoproteome analysis reveals redox switch in Akt. Nat Commun. 2019 Dec 2;10(1):5486. doi: 10.1038/s41467-019-13114-4.
  2. Khuong TM, Wang QP, Manion J, Oyston LJ, Lau MT, Towler H, Lin YQ, Neely GG. Nerve injury drives a heightened state of vigilance and neuropathic sensitization in Drosophila. Sci Adv. 2019 Jul; 5(7):eaaw4099.(IF:11.5)
  3. May CE, Vaziri A, Lin YQ, Grushko O, Khabiri M, Wang QP, Holme KJ, Pletcher SD, Freddolino PL, Neely GG, Dus M. High Dietary Sugar Reshapes Sweet Taste to Promote Feeding Behavior in Drosophila melanogaster. Cell Rep. 2019 May 7;27(6):1675-1685.e7. doi: 10.1016/j.celrep.2019.04.027. (IF:7.8)
  4. Samantha M. Solon-Biet, Victoria C. Cogger, Tamara Pulpitel, Devin Wahl, Ximonie Clark, Elena E. Bagley, Gabrielle C. Gregoriou, Alistair M. Senior, Qiao-Ping Wang, Amanda E. Brandon, Ruth Perks, John O’Sullivan, Yen Chin Koay, Kim Bell-Anderson, Melkam Kebede, Belinda Yau, Clare Atkinson, Gunbjorg Svineng, Tim Dodgson, Jibran A. Wali, Matthew D. W. Piper, Paula Juricic, Linda Partridge, Adam J. Rose, David Raubenheimer, Gregory J. Cooney, David G. Le Couteur, Stephen J. Simpson. Branched-chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control. Nat Metab, 2019; DOI: 10.1038/s42255-019-0059-2
  5. Lau MT, Manion J, Littleboy JB, Oyston L, Khuong TM, Wang QP, Nguyen DT, Hesselson D, Seymour JE, Neely GG. Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote. Nat Commun. 2019 Apr 30;10(1):1655. doi: 10.1038/s41467-019-09681-1(IF:11.9)
  6. Valsesia A*, Wang QP*, Gheldof N, Carayol J, Ruffieux H, Clark T, Shenton V, Oyston LJ, Lefebvre G, Metairon S, Chabert C, Walter O, Mironova P, Lau P, Descombes P, Viguerie N, Langin D, Harper ME, Astrup A, Saris WH, Dent R, Neely GG, Hager J.  Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism. Nat Commun. 2019 Feb 1;10(1):540. 10.1038/s41467-019-08492-8 (*co-first author, IF:11.9)

 

****2018****

  1. Wahl D, Solon-Biet SM, Wang QP, Wali JA, Pulpitel T, Clark X, Raubenheimer D, Senior AM, Sinclair DA, Cooney GJ, de Cabo R, Cogger VC, Simpson SJ, Le Couteur DG. Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice. Cell Rep. 2018 Nov 20;25(8):2234-2243.e6. doi: 10.1016/j.celrep.2018.10.070. (IF:7.8)
  2. Yang G, Humphrey SJ, Murashige DS, Francis D, Wang QP, Cooke KC, Neely GG,James DE. RagC Phosphorylation Autoregulates mTOR Complex. EMBO 2018 DOI: 10.15252/embj.201899548.  (IF:11.2)
  3. Oyston LJ, Lin YQ, Khuong, TM, Wang QP, Lau MT, Clark T and Neely GG. Neuronal Lamin regulates motor circuit integrity and controls motor function and lifespan. Cell Stress 2018, Vol. 2, No. 9, pp. 225 - 232; doi: 10.15698/cst2018.09.152
  4. Wang QP*#, Browman D*, Herzog H, Neely GG#. Non-nutritive sweeteners possess a bacteriostatic effect and alter gut microbiota in mice. PLoS One. 2018 Jul 5;13(7): e0199080. doi: 10.1371/journal.pone.0199080. eCollection 2018. (*co-first and #corresponding author, IF:2.8）
     

****2017****

  1. Lau MT, Lin YQ, Kisling S, Cotterell J, Wilson YA, Wang QP, Khuong TM, Bakhshi N, Cole TA, Oyston LJ, Cole AR, Neely GG. A simple high throughput assay to evaluate water consumption in the fruit fly. Sci Rep. 2017 Dec 1;7(1):16786. doi: 10.1038/s41598-017-16849-6. （IF:4.5）
  2. Wang QP, Simpson SJ, Herzog H, Neely GG. Chronic Sucralose or L-Glucose Ingestion Does Not Suppress Food Intake. Cell Metab. 2017;26(2):279-280（IF:22.4）
  3. Wong AC, Wang QP, Morimoto J, Senior AM, Lihoreau M, Neely GG, Simpson SJ, Ponton F. Gut microbiota modifies olfactory-guided microbial attraction in Drosophila. Curr Biol. 2017 ;27(15):2397-2404（IF:9.2）
  4. Loh K, Zhang L, Brandon A, Wang Q, Begg D, Qi Y, Fu M, Kulkarni R, Teo J, Baldock P, Brüning JC, Cooney G, Neely G, Herzog H. Insulin controls food intake and energy balance via NPY neurons. Mol Metab. 2017;6(6):574-584（IF:6.3）

 

****2016****

  1. Wang QP, Lin YQ, Zhang L, Wilson YA, Oyston LJ, Cotterell J, Qi Y, Khuong TM, Bakhshi N, Planchenault Y, Browman DT, Lau MT, Cole TA, Wong AC, Simpson SJ, Cole AR, Penninger JM, Herzog H, Neely GG. Sucralose Promotes Food Intake through NPY and a Neuronal Fasting Response. Cell Metab. 2016 Jul 12;24(1):75-90 (selected as Nature research highlight and Sci Signaling editorial，BBC news reported,  IF:22.4）

 

****2015****

  1. Peters MJ, Joehanes R, Pilling LC, Schurmann C, Conneely KN, Powell J, Reinmaa E, Sutphin GL, Zhernakova A, Schramm K, Wilson YA, Kobes S, Tukiainen T; NABEC/UKBEC Consortium, Ramos YF, Göring HH, Fornage M, Liu Y, Gharib SA, Stranger BE, De Jager PL, Aviv A, Levy D, Murabito JM, Munson PJ, Huan T, Hofman A, Uitterlinden AG, Rivadeneira F, van Rooij J, Stolk L, Broer L, Verbiest MM, Jhamai M, Arp P, Metspalu A, Tserel L, Milani L, Samani NJ, Peterson P, Kasela S, Codd V, Peters A, Ward-Caviness CK, Herder C, Waldenberger M, Roden M, Singmann P, Zeilinger S, Illig T, Homuth G, Grabe HJ, Völzke H, Steil L, Kocher T, Murray A, Melzer D, Yaghootkar H, Bandinelli S, Moses EK, Kent JW, Curran JE, Johnson MP, Williams-Blangero S, Westra HJ, McRae AF, Smith JA, Kardia SL, Hovatta I, Perola M, Ripatti S, Salomaa V, Henders AK, Martin NG, Smith AK, Mehta D, Binder EB, Nylocks KM, Kennedy EM, Klengel T, Ding J, Suchy-Dicey AM, Enquobahrie DA, Brody J, Rotter JI, Chen YD, Houwing-Duistermaat J, Kloppenburg M, Slagboom PE, Helmer Q, den Hollander W, Bean S, Raj T, Bakhshi N, Wang QP, Oyston LJ, Psaty BM, Tracy RP, Montgomery GW, Turner ST, Blangero J, Meulenbelt I, Ressler KJ, Yang J, Franke L, Kettunen J, Visscher PM, Neely GG, Korstanje R, Hanson RL, Prokisch H, Ferrucci L, Esko T, Teumer A, van Meurs JB, Johnson AD. The transcriptional landscape of age in human peripheral blood. Nat Commun. 2015 Oct 22; 6:8570. doi: 10.1038/ncomms9570. (New York Times reported, IF:11.9）

 

****Pre-2015****

  1. Neely GG, Keene AC, Duchek P, Chang EC, Wang QP, Aksoy YA, Rosenzweig M, Costigan M, Woolf CJ, Garrity PA, Penninger JM. TrpA1 regulates thermal nociception in Drosophila. PLoS One. 2011; 6(8): e24343. (IF:2.8）
  2. Wang QP, Wu ZD, Wei J, Owen RL, Lun ZR. Human Angiostrongylus cantonensis: an update. Eur J Clin Microbiol Infect Dis. 2012; 31(4): 389-95. 
  3. Wang QP, Lai DH, Li Z, Li FJ, Lun ZR. Semicarbazide-sensitive amine oxidases kill African trypanosomes.  Acta Tropica. 2011; 117:161-4.
  4. Wang QP, Kawahara T, Horn D. Histone deacetylases play distinct roles in telomeric VSG expression site silencing African trypanosomes. Mol Microbiol 2010; 77: 1237–1245. 
  5. Lai DH, Wang QP, Li Z, Luckins AG, Reid SA, Lun ZR. Investigations into human serum sensitivity expressed by stocks of Trypanosoma brucei evansi. Int J Parasitol 2010; 40:705-10. 
  6. Lai DH, Wang QP,  Li Z , Lukeš J, Lun ZR . Evolution of the serum resistance-associated SRA gene in African trypanosomes. Chin. Sci. Bull. 2009; 54:1275-1278. 
  7. Wang QP, Lai DH, Zhu XQ, Chen XG, Lun ZR. Human angiostrongyliasis. Lancet Infect Dis 2008; 10: 621-630. (IF:27.5）
  8. Lai DH, Wang QP, Chen W, Cai LS, Wu ZD, Zhu XQ, Lun ZR.  Molecular genetic profiles among individual Clonorchis sinensis adults collected from cats in two geographic regions of China revealed by RAPD and MGE-PCR methods. Acta Trop 2008; 107: 213-6. 
  9. Lun ZR, Wang QP, Chen XG, Li AX, Zhu XQ. Streptococcus suis: an emerging zoonotic pathogen. Lancet Infect Dis 2007; 7: 201-209. (IF:27.5）
  10. Wang QP, Chen XG, Lun ZR. Invasive fresh water snail, China. Emerg Infect Dis 2007; 13:1119-20. (IF:7.4）

 

****Book chapters****

****Pre-2015****

  1. Wang QP and Lun ZR . Angiostrongylus cantonensis and human angiostrongyliasis. In: TR Torgerson et al, editors. Zoonoses: Biology, Clinical Practice, and Public Health Control. Oxford University press 2011. Oxford UK. 
  2. Wang QP and Lun ZR . Steptococcus suis: the threat remains. In: Scheld WM, Hammer SM, Hughes JM editors. Emerging Infection 8. ASM Press 2009, Washington, DC .

 

****发明专利****